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• W2000561621 endingPage "1754" @default.
• W2000561621 startingPage "1745" @default.
• W2000561621 abstract "The voltage-dependent anion channel (VDAC), located at the outer mitochondria membrane (OMM), mediates interactions between mitochondria and other parts of the cell by transporting anions, cations, ATP, Ca2 +, and metabolites. Substantial evidence points to VDAC1 as being a key player in apoptosis, regulating the release of apoptogenic proteins from mitochondria, such as cytochrome c, and interacting with anti-apoptotic proteins. Recently, we demonstrated that VDAC1 oligomerization is a general mechanism common to numerous apoptogens acting via different initiating cascades and proposed that a protein-conducting channel formed within a VDAC1 homo/hetero oligomer mediates cytochrome c release. However, the molecular mechanism responsible for VDAC1 oligomerization remains unclear. Several studies have shown that mitochondrial Ca2 + is involved in apoptosis induction and that VDAC1 possesses Ca2 +-binding sites and mediates Ca2 + transport across the OMM. Here, the relationship between the cellular Ca2 + level, [Ca2 +]i, VDAC1 oligomerization and apoptosis was studied. Decreasing [Ca2 +]i using the cell-permeable Ca2 + chelating reagent BAPTA-AM was found to inhibit VDAC1 oligomerization and apoptosis, while increasing [Ca2 +]i using Ca2 + ionophore resulted in VDAC1 oligomerization and apoptosis induction in the absence of apoptotic stimuli. Moreover, induction of apoptosis elevated [Ca2 +]i, concomitantly with VDAC1 oligomerization. AzRu-mediated inhibition of mitochondrial Ca2 + transport decreased VDAC1 oligomerization, suggesting that mitochondrial Ca2 + is required for VDAC1 oligomerization. In addition, increased [Ca2 +]i levels up-regulate VDAC1 expression. These results suggest that Ca2 + promotes VDAC1 oligomerization via activation of a yet unknown signaling pathway or by increasing VDAC1 expression, leading to apoptosis. This article is part of a Special Issue entitled: 12th European Symposium on Calcium." @default.
• W2000561621 created "2016-06-24" @default.
• W2000561621 creator A5000188541 @default.
• W2000561621 creator A5014499512 @default.
• W2000561621 creator A5015589247 @default.
• W2000561621 creator A5087619047 @default.
• W2000561621 date "2013-07-01" @default.
• W2000561621 modified "2023-09-27" @default.
• W2000561621 title "The role of calcium in VDAC1 oligomerization and mitochondria-mediated apoptosis" @default.
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• W2000561621 doi "https://doi.org/10.1016/j.bbamcr.2013.03.017" @default.
• W2000561621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23542128" @default.
• W2000561621 hasPublicationYear "2013" @default.
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