Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000561714> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2000561714 endingPage "35" @default.
- W2000561714 startingPage "31" @default.
- W2000561714 abstract "Liver micronucleus (MN) tests using partial hepatectomized rats or juvenile rats have been shown to be useful for the detection of hepatic carcinogens. Moreover, Narumi et al. established the repeated-dose liver MN test using young adult rats for integration into general toxicity. In the present study, in order to examine the usefulness of the repeated-dose liver MN test, we investigated MN induction with a 14 or 28 day treatment protocol using young adult rats treated with 4,4′-methylenedianiline (MDA), a known hepatic carcinogen. MDA dose-dependently induced micronuclei in hepatocytes in 14- and 28-day repeated-dose tests. However, although statistically significant increases in micronuclei were observed in bone marrow cells at two dose levels in the 14-day study, there was no dose response and no increases in micronuclei in the 28-day study. These results indicate that the evaluation of genotoxic effects using hepatocytes is effective in cases where chromosomal aberrations are not clearly detectable in bone marrow cells. Moreover, the repeated-dose liver MN test allows evaluation at a dose below the maximum tolerable dose, which is required for the conventional MN test because micronucleated hepatocytes accumulate. The repeated-dose liver MN test employed in the present study can be integrated into the spectrum of general toxicity tests without further procedural modifications." @default.
- W2000561714 created "2016-06-24" @default.
- W2000561714 creator A5008547354 @default.
- W2000561714 creator A5016516587 @default.
- W2000561714 creator A5057164717 @default.
- W2000561714 creator A5068085304 @default.
- W2000561714 creator A5075741386 @default.
- W2000561714 date "2015-03-01" @default.
- W2000561714 modified "2023-09-27" @default.
- W2000561714 title "Repeated-dose liver micronucleus test of 4,4′-methylenedianiline using young adult rats" @default.
- W2000561714 cites W1969978690 @default.
- W2000561714 cites W1978944567 @default.
- W2000561714 cites W1995542624 @default.
- W2000561714 cites W1997209017 @default.
- W2000561714 cites W2003767111 @default.
- W2000561714 cites W2006927103 @default.
- W2000561714 cites W2018116549 @default.
- W2000561714 cites W2033261655 @default.
- W2000561714 cites W2041976716 @default.
- W2000561714 cites W2042309603 @default.
- W2000561714 cites W2046908575 @default.
- W2000561714 cites W2066095949 @default.
- W2000561714 cites W2112503611 @default.
- W2000561714 cites W2134524552 @default.
- W2000561714 cites W2137506218 @default.
- W2000561714 cites W2138026783 @default.
- W2000561714 cites W29865316 @default.
- W2000561714 doi "https://doi.org/10.1016/j.mrgentox.2014.06.001" @default.
- W2000561714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26065308" @default.
- W2000561714 hasPublicationYear "2015" @default.
- W2000561714 type Work @default.
- W2000561714 sameAs 2000561714 @default.
- W2000561714 citedByCount "5" @default.
- W2000561714 countsByYear W20005617142015 @default.
- W2000561714 countsByYear W20005617142018 @default.
- W2000561714 countsByYear W20005617142022 @default.
- W2000561714 crossrefType "journal-article" @default.
- W2000561714 hasAuthorship W2000561714A5008547354 @default.
- W2000561714 hasAuthorship W2000561714A5016516587 @default.
- W2000561714 hasAuthorship W2000561714A5057164717 @default.
- W2000561714 hasAuthorship W2000561714A5068085304 @default.
- W2000561714 hasAuthorship W2000561714A5075741386 @default.
- W2000561714 hasConcept C114246631 @default.
- W2000561714 hasConcept C126322002 @default.
- W2000561714 hasConcept C16685009 @default.
- W2000561714 hasConcept C2778959862 @default.
- W2000561714 hasConcept C2780007613 @default.
- W2000561714 hasConcept C29730261 @default.
- W2000561714 hasConcept C33070731 @default.
- W2000561714 hasConcept C36681516 @default.
- W2000561714 hasConcept C42407357 @default.
- W2000561714 hasConcept C45080847 @default.
- W2000561714 hasConcept C54355233 @default.
- W2000561714 hasConcept C71924100 @default.
- W2000561714 hasConcept C86803240 @default.
- W2000561714 hasConcept C98274493 @default.
- W2000561714 hasConceptScore W2000561714C114246631 @default.
- W2000561714 hasConceptScore W2000561714C126322002 @default.
- W2000561714 hasConceptScore W2000561714C16685009 @default.
- W2000561714 hasConceptScore W2000561714C2778959862 @default.
- W2000561714 hasConceptScore W2000561714C2780007613 @default.
- W2000561714 hasConceptScore W2000561714C29730261 @default.
- W2000561714 hasConceptScore W2000561714C33070731 @default.
- W2000561714 hasConceptScore W2000561714C36681516 @default.
- W2000561714 hasConceptScore W2000561714C42407357 @default.
- W2000561714 hasConceptScore W2000561714C45080847 @default.
- W2000561714 hasConceptScore W2000561714C54355233 @default.
- W2000561714 hasConceptScore W2000561714C71924100 @default.
- W2000561714 hasConceptScore W2000561714C86803240 @default.
- W2000561714 hasConceptScore W2000561714C98274493 @default.
- W2000561714 hasLocation W20005617141 @default.
- W2000561714 hasLocation W20005617142 @default.
- W2000561714 hasOpenAccess W2000561714 @default.
- W2000561714 hasPrimaryLocation W20005617141 @default.
- W2000561714 hasRelatedWork W2078241954 @default.
- W2000561714 hasRelatedWork W2081304903 @default.
- W2000561714 hasRelatedWork W2091355127 @default.
- W2000561714 hasRelatedWork W2105153492 @default.
- W2000561714 hasRelatedWork W2148454982 @default.
- W2000561714 hasRelatedWork W2152020594 @default.
- W2000561714 hasRelatedWork W2792734714 @default.
- W2000561714 hasRelatedWork W3207677898 @default.
- W2000561714 hasRelatedWork W395963736 @default.
- W2000561714 hasRelatedWork W2181729972 @default.
- W2000561714 hasVolume "780-781" @default.
- W2000561714 isParatext "false" @default.
- W2000561714 isRetracted "false" @default.
- W2000561714 magId "2000561714" @default.
- W2000561714 workType "article" @default.