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- W2000561912 abstract "CpG motifs have been advanced as agents that stimulate the maturation of DCs for immunotherapy. The present study tested the hypothesis that multiple doses of CpG-matured DC vaccine would be efficacious for complete eradication of experimentally-induced tumor. Accordingly, WEHI164 cells were implanted subcutaneously in the flank of BALB/c mice. During DC culture, tumor lysate was added to immature DCs followed by addition of CpG or non-CpG control 4-6h later. A total of three doses of CpG or non-CpG control-matured DCs were injected around tumors. The results showed that multiple doses of CpG-matured DCs led to considerable decrease in cytotoxicity of lymphocytes and significantly increased tumor growth rate compared to a single dose. Further, mice which received three doses of the vaccine also displayed significant FoxP3 in tumor tissue. In conclusion, multiple doses of CpG-matured DCs exhibited decreased anti-tumor immunity in association with increased expression of FoxP3." @default.
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- W2000561912 date "2011-01-01" @default.
- W2000561912 modified "2023-09-26" @default.
- W2000561912 title "Reduced efficacy of multiple doses of CpG-matured dendritic cell tumor vaccine in an experimental model" @default.
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- W2000561912 doi "https://doi.org/10.1016/j.cellimm.2011.08.001" @default.
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