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- W2000561941 abstract "We synthesized various 6-fluoro-7-(1-piperazino)quinazolines based on the structure of 1 and evaluated their inhibitory activities toward both TNF-alpha production and T cell proliferation responses. Among these compounds, 7a, having the 3,4-(methylenedioxy)phenyl moiety at the C(4)-position of the quinazoline ring, showed both inhibitory activities. Furthermore, the oral treatment with 7a exhibited an anti-inflammatory effect in rats with adjuvant arthritis as well as an inhibitory activity toward LPS-induced TNF-alpha production." @default.
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- W2000561941 date "2003-02-01" @default.
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- W2000561941 title "Structure–Activity relationships of 6-fluoroquinazolines: dual-Acting compounds with inhibitory activities toward both TNF-α production and T cell proliferation" @default.
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- W2000561941 doi "https://doi.org/10.1016/s0968-0896(02)00338-3" @default.
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