FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000562891> ?p ?o ?g. }

• W2000562891 endingPage "100" @default.
• W2000562891 startingPage "91" @default.
• W2000562891 abstract "The in vitro metabolism of a polychlorinated biphenyl (PCB) mixture was examined using hepatic microsomes of dietary-exposed Greenland sledge dogs (Canis familiaris) to an organohalogen-rich diet (Greenland minke whale blubber: EXP cohort) or a control diet (pork fat: CON cohort). The associations between in vitro PCB metabolism, activity of oxidative hepatic microsomal cytochrome P450 (CYP) isoenzymes and concentrations of PCBs and hydroxylated metabolites were investigated. The CON dogs exhibited a 2.3-fold higher depletion percentage for the PCB congeners having at least two pairs of vicinal meta-para Cl-unsubstituted carbons (PCB-18 and -33) relative to the EXP dogs. This depletion discrepancy suggests that there exist substrates in liver of the organohalogen-contaminated EXP dogs that can competitively bind and/or interfere with the active sites of CYP isoenzymes, leading to a lower metabolic efficiency for these PCBs. Testosterone (T) hydroxylase activity, determined via the formation of 6beta-OH-T, 16alpha-OH-T, 16beta-OH-T and androstenedione, was strongly correlated with the depletion percentages of PCB-18 and -33 in both cohorts. Based on documented hepatic microsomal CYP isoenzyme substrate specificities in canines, present associations suggest that primarily CYP2B/2C and CYP3A were inducible in sledge dogs and responsible for the in vitro metabolism of PCB-18 and -33." @default.
• W2000562891 created "2016-06-24" @default.
• W2000562891 creator A5014875979 @default.
• W2000562891 creator A5028326798 @default.
• W2000562891 creator A5079249263 @default.
• W2000562891 creator A5090811204 @default.
• W2000562891 date "2009-07-01" @default.
• W2000562891 modified "2023-10-14" @default.
• W2000562891 title "In vitro metabolism of polychlorinated biphenyls and cytochrome P450 monooxygenase activities in dietary-exposed Greenland sledge dogs" @default.
• W2000562891 cites W1968651135 @default.
• W2000562891 cites W1973323848 @default.
• W2000562891 cites W1976652097 @default.
• W2000562891 cites W1977689977 @default.
• W2000562891 cites W1982747463 @default.
• W2000562891 cites W1982916229 @default.
• W2000562891 cites W1985176156 @default.
• W2000562891 cites W1997546586 @default.
• W2000562891 cites W1998241556 @default.
• W2000562891 cites W2001019573 @default.
• W2000562891 cites W2005576645 @default.
• W2000562891 cites W2006809144 @default.
• W2000562891 cites W2011245669 @default.
• W2000562891 cites W2012448363 @default.
• W2000562891 cites W2017512332 @default.
• W2000562891 cites W2031489575 @default.
• W2000562891 cites W2031638439 @default.
• W2000562891 cites W2032348454 @default.
• W2000562891 cites W2032482174 @default.
• W2000562891 cites W2048765628 @default.
• W2000562891 cites W2049759748 @default.
• W2000562891 cites W2049768900 @default.
• W2000562891 cites W2051604373 @default.
• W2000562891 cites W2052428509 @default.
• W2000562891 cites W2062479405 @default.
• W2000562891 cites W2070878421 @default.
• W2000562891 cites W2080047772 @default.
• W2000562891 cites W2081155141 @default.
• W2000562891 cites W2082046823 @default.
• W2000562891 cites W2083280361 @default.
• W2000562891 cites W2089930457 @default.
• W2000562891 cites W2091583619 @default.
• W2000562891 cites W2093113482 @default.
• W2000562891 cites W2106478633 @default.
• W2000562891 cites W2109657588 @default.
• W2000562891 cites W2110447885 @default.
• W2000562891 cites W2110856690 @default.
• W2000562891 cites W2114658334 @default.
• W2000562891 cites W2134857282 @default.
• W2000562891 cites W2135285043 @default.
• W2000562891 cites W2154577090 @default.
• W2000562891 cites W2163860077 @default.
• W2000562891 cites W2168503662 @default.
• W2000562891 cites W4323915796 @default.
• W2000562891 doi "https://doi.org/10.1016/j.cbpc.2009.03.004" @default.
• W2000562891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19303460" @default.
• W2000562891 hasPublicationYear "2009" @default.
• W2000562891 type Work @default.
• W2000562891 sameAs 2000562891 @default.
• W2000562891 citedByCount "7" @default.
• W2000562891 countsByYear W20005628912013 @default.
• W2000562891 countsByYear W20005628912016 @default.
• W2000562891 countsByYear W20005628912018 @default.
• W2000562891 countsByYear W20005628912021 @default.
• W2000562891 countsByYear W20005628912022 @default.
• W2000562891 crossrefType "journal-article" @default.
• W2000562891 hasAuthorship W2000562891A5014875979 @default.
• W2000562891 hasAuthorship W2000562891A5028326798 @default.
• W2000562891 hasAuthorship W2000562891A5079249263 @default.
• W2000562891 hasAuthorship W2000562891A5090811204 @default.
• W2000562891 hasConcept C107872376 @default.
• W2000562891 hasConcept C11824378 @default.
• W2000562891 hasConcept C126322002 @default.
• W2000562891 hasConcept C134018914 @default.
• W2000562891 hasConcept C185592680 @default.
• W2000562891 hasConcept C202751555 @default.
• W2000562891 hasConcept C2776365360 @default.
• W2000562891 hasConcept C526171541 @default.
• W2000562891 hasConcept C55493867 @default.
• W2000562891 hasConcept C62231903 @default.
• W2000562891 hasConcept C71924100 @default.
• W2000562891 hasConcept C86803240 @default.
• W2000562891 hasConcept C87644729 @default.
• W2000562891 hasConceptScore W2000562891C107872376 @default.
• W2000562891 hasConceptScore W2000562891C11824378 @default.
• W2000562891 hasConceptScore W2000562891C126322002 @default.
• W2000562891 hasConceptScore W2000562891C134018914 @default.
• W2000562891 hasConceptScore W2000562891C185592680 @default.
• W2000562891 hasConceptScore W2000562891C202751555 @default.
• W2000562891 hasConceptScore W2000562891C2776365360 @default.
• W2000562891 hasConceptScore W2000562891C526171541 @default.
• W2000562891 hasConceptScore W2000562891C55493867 @default.
• W2000562891 hasConceptScore W2000562891C62231903 @default.
• W2000562891 hasConceptScore W2000562891C71924100 @default.
• W2000562891 hasConceptScore W2000562891C86803240 @default.
• W2000562891 hasConceptScore W2000562891C87644729 @default.
• W2000562891 hasIssue "1" @default.
• W2000562891 hasLocation W20005628911 @default.
• W2000562891 hasLocation W20005628912 @default.

• next