FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000563705> ?p ?o ?g. }

• W2000563705 endingPage "3013" @default.
• W2000563705 startingPage "3003" @default.
• W2000563705 abstract "Stromal interaction molecule 1 (STIM1) is a Ca(2+) sensor protein that initiates store-operated calcium entry (SOCE). STIM1 is known to be involved in the chemoattractant signaling pathway for FPR1 in cell lines, but its role in in vivo functioning of neutrophils is unclear. Plaque-type psoriasis is a chronic inflammatory skin disorder associated with chemoattractants driving neutrophils into the epidermis. We investigated the involvement of STIM1 in neutrophil chemotaxis in vitro, as well as during chronic psoriatic inflammation. To this end, we used conditional knockout (KO) mice lacking STIM1 in cells of myeloid lineage (STIM1(fl/fl) LysM-cre). We demonstrate that STIM1 is required for chemotaxis because of multiple chemoattractants in mouse neutrophils in vitro. Using an imiquimod-induced psoriasis-like skin model, we show that KO mice had less neutrophil infiltration in the epidermis than controls, whereas neither chemoattractant production in the epidermis nor macrophage migration was decreased. KO mice displayed a more rapid reversal of the outward signs of psoriasis (plaques). Thus, KO of STIM1 impairs neutrophil contribution to psoriatic inflammation. Our data provide new insights to our understanding of how STIM1 orchestrates the cellular behavior underlying chemotaxis and illustrate the important role of SOCE in a disease-related pathologic model." @default.
• W2000563705 created "2016-06-24" @default.
• W2000563705 creator A5007667147 @default.
• W2000563705 creator A5023459176 @default.
• W2000563705 creator A5041409821 @default.
• W2000563705 creator A5046301605 @default.
• W2000563705 creator A5060890309 @default.
• W2000563705 creator A5066980743 @default.
• W2000563705 creator A5080631544 @default.
• W2000563705 date "2015-04-02" @default.
• W2000563705 modified "2023-09-27" @default.
• W2000563705 title "Role of the store‐operated calcium entry protein, STIM1, in neutrophil chemotaxis and infiltration into a murine model of psoriasis‐inflamed skin" @default.
• W2000563705 cites W1595293335 @default.
• W2000563705 cites W1675540441 @default.
• W2000563705 cites W1939997832 @default.
• W2000563705 cites W1967265143 @default.
• W2000563705 cites W1984695120 @default.
• W2000563705 cites W1990435317 @default.
• W2000563705 cites W1999709334 @default.
• W2000563705 cites W2012097026 @default.
• W2000563705 cites W2014520088 @default.
• W2000563705 cites W2022548775 @default.
• W2000563705 cites W2047118128 @default.
• W2000563705 cites W2059325716 @default.
• W2000563705 cites W2067391845 @default.
• W2000563705 cites W2070994939 @default.
• W2000563705 cites W2073891485 @default.
• W2000563705 cites W2080658642 @default.
• W2000563705 cites W2091150961 @default.
• W2000563705 cites W2095395089 @default.
• W2000563705 cites W2096331437 @default.
• W2000563705 cites W2104180154 @default.
• W2000563705 cites W2109594922 @default.
• W2000563705 cites W2118988881 @default.
• W2000563705 cites W2128445597 @default.
• W2000563705 cites W2129496249 @default.
• W2000563705 cites W2130058588 @default.
• W2000563705 cites W2146341872 @default.
• W2000563705 cites W2155582127 @default.
• W2000563705 cites W2156108086 @default.
• W2000563705 cites W2159543436 @default.
• W2000563705 cites W2161210718 @default.
• W2000563705 cites W2163789582 @default.
• W2000563705 cites W2164048978 @default.
• W2000563705 cites W2169584153 @default.
• W2000563705 cites W2345689701 @default.
• W2000563705 cites W2561759163 @default.
• W2000563705 doi "https://doi.org/10.1096/fj.14-265215" @default.
• W2000563705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4478797" @default.
• W2000563705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25837581" @default.
• W2000563705 hasPublicationYear "2015" @default.
• W2000563705 type Work @default.
• W2000563705 sameAs 2000563705 @default.
• W2000563705 citedByCount "32" @default.
• W2000563705 countsByYear W20005637052015 @default.
• W2000563705 countsByYear W20005637052016 @default.
• W2000563705 countsByYear W20005637052017 @default.
• W2000563705 countsByYear W20005637052018 @default.
• W2000563705 countsByYear W20005637052019 @default.
• W2000563705 countsByYear W20005637052020 @default.
• W2000563705 countsByYear W20005637052021 @default.
• W2000563705 countsByYear W20005637052022 @default.
• W2000563705 countsByYear W20005637052023 @default.
• W2000563705 crossrefType "journal-article" @default.
• W2000563705 hasAuthorship W2000563705A5007667147 @default.
• W2000563705 hasAuthorship W2000563705A5023459176 @default.
• W2000563705 hasAuthorship W2000563705A5041409821 @default.
• W2000563705 hasAuthorship W2000563705A5046301605 @default.
• W2000563705 hasAuthorship W2000563705A5060890309 @default.
• W2000563705 hasAuthorship W2000563705A5066980743 @default.
• W2000563705 hasAuthorship W2000563705A5080631544 @default.
• W2000563705 hasBestOaLocation W20005637052 @default.
• W2000563705 hasConcept C118995209 @default.
• W2000563705 hasConcept C121332964 @default.
• W2000563705 hasConcept C153400128 @default.
• W2000563705 hasConcept C158617107 @default.
• W2000563705 hasConcept C162740809 @default.
• W2000563705 hasConcept C170493617 @default.
• W2000563705 hasConcept C185592680 @default.
• W2000563705 hasConcept C202751555 @default.
• W2000563705 hasConcept C203014093 @default.
• W2000563705 hasConcept C2776914184 @default.
• W2000563705 hasConcept C2780564577 @default.
• W2000563705 hasConcept C54166955 @default.
• W2000563705 hasConcept C55493867 @default.
• W2000563705 hasConcept C86803240 @default.
• W2000563705 hasConcept C95444343 @default.
• W2000563705 hasConcept C97355855 @default.
• W2000563705 hasConceptScore W2000563705C118995209 @default.
• W2000563705 hasConceptScore W2000563705C121332964 @default.
• W2000563705 hasConceptScore W2000563705C153400128 @default.
• W2000563705 hasConceptScore W2000563705C158617107 @default.
• W2000563705 hasConceptScore W2000563705C162740809 @default.
• W2000563705 hasConceptScore W2000563705C170493617 @default.
• W2000563705 hasConceptScore W2000563705C185592680 @default.
• W2000563705 hasConceptScore W2000563705C202751555 @default.
• W2000563705 hasConceptScore W2000563705C203014093 @default.
• W2000563705 hasConceptScore W2000563705C2776914184 @default.

• next