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- W2000563952 abstract "The action of proline and its analog as glutamate antagonists was investigated in CNS tissue of the neonatal chick. Avian brain slices were incubated in low concentrations of L-proline, D-proline, DL-3,4-dehydro-proline, L-prolyl-L-proline, or in avian physiological salt solution before depolarization was induced by application of 45 mM K+. Glutamate was determined in the efflux material collected both before and after tissue stimulation. The release of endogenous glutamate was inhibited significantly by exposure to L-proline, DL-3,4-dehydroproline and L-prolyl-L-proline. The degree of glutamate inhibition correlated with the amnestic potency of these substances. The manner in which these results strengthen the hypothesis of glutamate involvement in memory processes is discussed." @default.
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- W2000563952 date "1983-08-01" @default.
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- W2000563952 title "Brain glutamate inhibition and amnesia: evidence provided by proline analog action" @default.
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- W2000563952 doi "https://doi.org/10.1016/0165-3806(83)90056-1" @default.
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