FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000564108> ?p ?o ?g. }

• W2000564108 endingPage "1083" @default.
• W2000564108 startingPage "1071" @default.
• W2000564108 abstract "Sustained contraction of cells depends on sustained Rho-associated kinase (Rho-kinase) activation. We developed a computational model of the Rho-kinase pathway to understand the systems characteristics. Thrombin-dependent in vivo transient responses of Rho activation and Ca2+ increase could be reproduced in silico. Low and high thrombin stimulation induced transient and sustained phosphorylation, respectively, of myosin light chain (MLC) and myosin phosphatase targeting subunit 1 (MYPT1) in vivo. The transient phosphorylation of MLC and MYPT1 could be reproduced in silico, but their sustained phosphorylation could not. This discrepancy between in vivo and in silico in the sustained responses downstream of Rho-kinase indicates that a missing pathway(s) may be responsible for the sustained Rho-kinase activation. We found, experimentally, that the sustained phosphorylation of MLC and MYPT1 exhibit all-or-none responses. Bromoenol lactone, a specific inhibitor of Ca2+ -independent phospholipase A2 (iPLA2), inhibited sustained phosphorylation of MLC and MYPT1, which indicates that sustained Rho-kinase activation requires iPLA2 activity. Thus, the systems analysis of the Rho-kinase pathway identified a novel iPLA2-dependent mechanism of the sustained Rho-kinase activation, which exhibits an all-or-none response." @default.
• W2000564108 created "2016-06-24" @default.
• W2000564108 creator A5011472740 @default.
• W2000564108 creator A5012487815 @default.
• W2000564108 creator A5026605269 @default.
• W2000564108 creator A5035549362 @default.
• W2000564108 creator A5042710232 @default.
• W2000564108 creator A5043066066 @default.
• W2000564108 creator A5055848943 @default.
• W2000564108 creator A5067854107 @default.
• W2000564108 creator A5083727386 @default.
• W2000564108 date "2006-07-28" @default.
• W2000564108 modified "2023-10-17" @default.
• W2000564108 title "Ca²⁺‐independent phospholipase A2‐dependent sustained Rho‐kinase activation exhibits all‐or‐none response" @default.
• W2000564108 cites W1516262714 @default.
• W2000564108 cites W1540285469 @default.
• W2000564108 cites W1597787921 @default.
• W2000564108 cites W1755902553 @default.
• W2000564108 cites W1867109858 @default.
• W2000564108 cites W1974861666 @default.
• W2000564108 cites W1978139515 @default.
• W2000564108 cites W1993379452 @default.
• W2000564108 cites W1997087774 @default.
• W2000564108 cites W2007513694 @default.
• W2000564108 cites W2008855387 @default.
• W2000564108 cites W2011826166 @default.
• W2000564108 cites W2015836314 @default.
• W2000564108 cites W2023410176 @default.
• W2000564108 cites W2033629898 @default.
• W2000564108 cites W2034679499 @default.
• W2000564108 cites W2035128610 @default.
• W2000564108 cites W2040422920 @default.
• W2000564108 cites W2056800516 @default.
• W2000564108 cites W2060189631 @default.
• W2000564108 cites W2065064471 @default.
• W2000564108 cites W2067577192 @default.
• W2000564108 cites W2068483215 @default.
• W2000564108 cites W2070626143 @default.
• W2000564108 cites W2071658020 @default.
• W2000564108 cites W2073079404 @default.
• W2000564108 cites W2083409781 @default.
• W2000564108 cites W2086262311 @default.
• W2000564108 cites W2096096080 @default.
• W2000564108 cites W2096498288 @default.
• W2000564108 cites W2107635756 @default.
• W2000564108 cites W2123880844 @default.
• W2000564108 cites W2129896811 @default.
• W2000564108 cites W2130172628 @default.
• W2000564108 cites W2133667940 @default.
• W2000564108 cites W2134342926 @default.
• W2000564108 cites W2138608519 @default.
• W2000564108 cites W2140920908 @default.
• W2000564108 cites W2144065167 @default.
• W2000564108 cites W2150317682 @default.
• W2000564108 cites W2152907506 @default.
• W2000564108 cites W2153624387 @default.
• W2000564108 cites W2154785597 @default.
• W2000564108 cites W2158516169 @default.
• W2000564108 cites W2170858841 @default.
• W2000564108 cites W2172210768 @default.
• W2000564108 cites W2198940906 @default.
• W2000564108 doi "https://doi.org/10.1111/j.1365-2443.2006.01001.x" @default.
• W2000564108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16923126" @default.
• W2000564108 hasPublicationYear "2006" @default.
• W2000564108 type Work @default.
• W2000564108 sameAs 2000564108 @default.
• W2000564108 citedByCount "30" @default.
• W2000564108 countsByYear W20005641082012 @default.
• W2000564108 countsByYear W20005641082013 @default.
• W2000564108 countsByYear W20005641082014 @default.
• W2000564108 countsByYear W20005641082015 @default.
• W2000564108 countsByYear W20005641082016 @default.
• W2000564108 countsByYear W20005641082017 @default.
• W2000564108 countsByYear W20005641082018 @default.
• W2000564108 countsByYear W20005641082019 @default.
• W2000564108 countsByYear W20005641082020 @default.
• W2000564108 countsByYear W20005641082022 @default.
• W2000564108 crossrefType "journal-article" @default.
• W2000564108 hasAuthorship W2000564108A5011472740 @default.
• W2000564108 hasAuthorship W2000564108A5012487815 @default.
• W2000564108 hasAuthorship W2000564108A5026605269 @default.
• W2000564108 hasAuthorship W2000564108A5035549362 @default.
• W2000564108 hasAuthorship W2000564108A5042710232 @default.
• W2000564108 hasAuthorship W2000564108A5043066066 @default.
• W2000564108 hasAuthorship W2000564108A5055848943 @default.
• W2000564108 hasAuthorship W2000564108A5067854107 @default.
• W2000564108 hasAuthorship W2000564108A5083727386 @default.
• W2000564108 hasBestOaLocation W20005641081 @default.
• W2000564108 hasConcept C11960822 @default.
• W2000564108 hasConcept C12554922 @default.
• W2000564108 hasConcept C12927208 @default.
• W2000564108 hasConcept C150903083 @default.
• W2000564108 hasConcept C181199279 @default.
• W2000564108 hasConcept C184235292 @default.
• W2000564108 hasConcept C201800478 @default.
• W2000564108 hasConcept C207001950 @default.
• W2000564108 hasConcept C2776551241 @default.
• W2000564108 hasConcept C2779938346 @default.

• next