FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000564722> ?p ?o ?g. }

• W2000564722 endingPage "149" @default.
• W2000564722 startingPage "141" @default.
• W2000564722 abstract "Vaginal and clitoral vasodilator responses (genital vascular responses; GVRs) to pelvic nerve electrical stimulation in female rabbits were measured by laser Doppler flow needle probes. The intravenous administration of various treatments was evaluated. GVRs were attenuated by a nitric-oxide synthase inhibitor (48.5 and 51.8% of control at 8 Hz in the vagina and clitoris, respectively) and norepinephrine (NE) (78.5 and 61.5%), whereas serotonin (5-HT) had no inhibitory effect. The selective 5-HT reuptake inhibitor (SSRI) escitalopram did not modify GVRs, whereas the SSRI paroxetine dose-dependently inhibited GVRs in female rabbits (43.3 and 53.1% at 5 mg/kg). GVRs were also significantly inhibited by the 5-HT and NE reuptake inhibitors venlafaxine (53.4 and 52.6% at 5 mg/kg) and duloxetine (40.9 and 37.4% at 1 mg/kg). L-arginine prevented the inhibitory effects of paroxetine (105.5 and 115.3%) and partially prevented duloxetine-induced reduction of GVRs but had no effect on the inhibition of GVRs induced by venlafaxine. Conversely, the alpha-adrenergic receptor blocker phentolamine had no effect on paroxetine-induced reduction of GVRs, partially prevented the inhibitory effects of duloxetine, and fully prevented the effects of venlafaxine (93.0 and 96.7%). Duloxetine-induced inhibition of GVRs was completely prevented by combined administration of L-arginine and phentolamine (123.5 and 103.6%). Although 5-HT or the highly selective SRI escitalopram did not inhibit GVRs, NE or inhibition of nitric oxide (NO) synthesis did. Inhibition of the NO pathway by paroxetine and duloxetine or activation of alpha-adrenergic mechanisms by venlafaxine and duloxetine lead to antidepressant-induced inhibition of GVRs in female rabbits." @default.
• W2000564722 created "2016-06-24" @default.
• W2000564722 creator A5019608297 @default.
• W2000564722 creator A5031618052 @default.
• W2000564722 creator A5033504541 @default.
• W2000564722 creator A5048482745 @default.
• W2000564722 creator A5069269686 @default.
• W2000564722 date "2004-03-19" @default.
• W2000564722 modified "2023-10-17" @default.
• W2000564722 title "Mechanisms for the Inhibition of Genital Vascular Responses by Antidepressants in a Female Rabbit Model" @default.
• W2000564722 cites W1518811922 @default.
• W2000564722 cites W1519701208 @default.
• W2000564722 cites W1661382262 @default.
• W2000564722 cites W1969839195 @default.
• W2000564722 cites W1979328473 @default.
• W2000564722 cites W1982721912 @default.
• W2000564722 cites W1989007151 @default.
• W2000564722 cites W1994371282 @default.
• W2000564722 cites W2001429488 @default.
• W2000564722 cites W2001724263 @default.
• W2000564722 cites W2004635749 @default.
• W2000564722 cites W2016023801 @default.
• W2000564722 cites W2017195140 @default.
• W2000564722 cites W2018008180 @default.
• W2000564722 cites W2018425549 @default.
• W2000564722 cites W2024450258 @default.
• W2000564722 cites W2035606229 @default.
• W2000564722 cites W2044359142 @default.
• W2000564722 cites W2049212547 @default.
• W2000564722 cites W2051093271 @default.
• W2000564722 cites W2052060051 @default.
• W2000564722 cites W2055709629 @default.
• W2000564722 cites W2061271938 @default.
• W2000564722 cites W2089526280 @default.
• W2000564722 cites W2093122198 @default.
• W2000564722 cites W2122779751 @default.
• W2000564722 cites W2124733814 @default.
• W2000564722 cites W2127317351 @default.
• W2000564722 cites W2142964535 @default.
• W2000564722 cites W2148875560 @default.
• W2000564722 cites W2154632051 @default.
• W2000564722 cites W2416917144 @default.
• W2000564722 cites W4246653384 @default.
• W2000564722 cites W4249162025 @default.
• W2000564722 doi "https://doi.org/10.1124/jpet.103.063362" @default.
• W2000564722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15034084" @default.
• W2000564722 hasPublicationYear "2004" @default.
• W2000564722 type Work @default.
• W2000564722 sameAs 2000564722 @default.
• W2000564722 citedByCount "10" @default.
• W2000564722 countsByYear W20005647222012 @default.
• W2000564722 countsByYear W20005647222013 @default.
• W2000564722 countsByYear W20005647222022 @default.
• W2000564722 crossrefType "journal-article" @default.
• W2000564722 hasAuthorship W2000564722A5019608297 @default.
• W2000564722 hasAuthorship W2000564722A5031618052 @default.
• W2000564722 hasAuthorship W2000564722A5033504541 @default.
• W2000564722 hasAuthorship W2000564722A5048482745 @default.
• W2000564722 hasAuthorship W2000564722A5069269686 @default.
• W2000564722 hasConcept C126322002 @default.
• W2000564722 hasConcept C134018914 @default.
• W2000564722 hasConcept C142724271 @default.
• W2000564722 hasConcept C170493617 @default.
• W2000564722 hasConcept C185592680 @default.
• W2000564722 hasConcept C204787440 @default.
• W2000564722 hasConcept C24998067 @default.
• W2000564722 hasConcept C2775864247 @default.
• W2000564722 hasConcept C2775893369 @default.
• W2000564722 hasConcept C2776466888 @default.
• W2000564722 hasConcept C2777490545 @default.
• W2000564722 hasConcept C2777828372 @default.
• W2000564722 hasConcept C2779177272 @default.
• W2000564722 hasConcept C2779583969 @default.
• W2000564722 hasConcept C2780253649 @default.
• W2000564722 hasConcept C2780764818 @default.
• W2000564722 hasConcept C2781161787 @default.
• W2000564722 hasConcept C31487548 @default.
• W2000564722 hasConcept C71924100 @default.
• W2000564722 hasConcept C98274493 @default.
• W2000564722 hasConceptScore W2000564722C126322002 @default.
• W2000564722 hasConceptScore W2000564722C134018914 @default.
• W2000564722 hasConceptScore W2000564722C142724271 @default.
• W2000564722 hasConceptScore W2000564722C170493617 @default.
• W2000564722 hasConceptScore W2000564722C185592680 @default.
• W2000564722 hasConceptScore W2000564722C204787440 @default.
• W2000564722 hasConceptScore W2000564722C24998067 @default.
• W2000564722 hasConceptScore W2000564722C2775864247 @default.
• W2000564722 hasConceptScore W2000564722C2775893369 @default.
• W2000564722 hasConceptScore W2000564722C2776466888 @default.
• W2000564722 hasConceptScore W2000564722C2777490545 @default.
• W2000564722 hasConceptScore W2000564722C2777828372 @default.
• W2000564722 hasConceptScore W2000564722C2779177272 @default.
• W2000564722 hasConceptScore W2000564722C2779583969 @default.
• W2000564722 hasConceptScore W2000564722C2780253649 @default.
• W2000564722 hasConceptScore W2000564722C2780764818 @default.
• W2000564722 hasConceptScore W2000564722C2781161787 @default.
• W2000564722 hasConceptScore W2000564722C31487548 @default.
• W2000564722 hasConceptScore W2000564722C71924100 @default.

• next