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- W2000565205 abstract "1. Microsomal and mitochondrial fractions were isolated from livers, kidneys and hearts of 6- and 24-month-old rats and the specific activities of several membrane-bound enzymes were determined. Differences were seen in the activities of the enzymes at the different ages. 2. The phospholipid to protein ratios of the isolated fractions were determined. The phospholipid of the liver and kidney microsomal fractions was decreased in the old animals. No changes were seen in the ratio of membrane phospholipid to total lipid. 3. Kinetic analysis was performed on two membrane-bound enzymes isolated from 6- and 24-month-old animals. Altered, perhaps inhibited, forms of the enzymes were indicated. 4. It is concluded that enzyme changes observed to occur during aging are not directly correlated with in vivo phospholipid loss. The regulating influence of membrane conformation on the activity of bound enzymes, however, does appear to change." @default.
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- W2000565205 date "1972-11-01" @default.
- W2000565205 modified "2023-09-23" @default.
- W2000565205 title "Age-related changes in membrane lipid content and enzyme activities" @default.
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- W2000565205 doi "https://doi.org/10.1016/0005-2736(72)90255-6" @default.
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