FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000566236> ?p ?o ?g. }

• W2000566236 endingPage "167" @default.
• W2000566236 startingPage "157" @default.
• W2000566236 abstract "During the 1960s, hypogonadotropic patients with polycystic ovary syndrome and those with clomiphene citrate resistance were the first to achieve pregnancy after urinary human menopausal gonadotropin (hMG) administration plus preovulatory human chorionic gonadotropin injection, with cumulative pregnancy rates ranging from 40% to 80% after six to 12 treatment cycles. Ever since, dramatically more progress has been achieved regarding methods and medication in assisted conception techniques, involving both a rapidly increased number of subfertile couples, as well as many practitioners in obstetrics and gynecology. The purpose of this review was to highlight the most crucial historical steps of this remarkable process, by emphasizing the role of gonadotropins in ovulation induction protocols according to the various clinical categories of subfertile patients. In the late 1970s, urinary hMG was the most widely used gonadotropin for ovarian stimulation during in vitro fertilization-embryo transfer for assisted reproduction. The often concurrent problems of premature luteinizing hormone (LH) surges and premature luteinizations, and thus cancellations of the cycles, were efficiently overcome by 'reversible medical hypophysectomy', performed by gonadotropin releasing hormone (GnRH) analogs, introduced in 1982. According to its initiation and duration, GnRH analog use was divided into three protocols: the long, most widely used, protocol, which was the best for suppression of endogenous, high tonic LH levels, especially in polycystic ovary syndrome and normogonadotropic patients; and the short and ultra-short protocols, which were mainly used in poor responders to ovarian stimulation treatment, older or hypergonadotropic patients with ovarian failure, because of the well-known 'flare-up phenomenon'. Recently, GnRH antagonists, which directly do not permit GnRH action by binding to the GnRH gonadotropic cell receptors, have been used, but no final results from large, multicenter clinical trials that are still being undertaken have yet been achieved. Various sub-products of urinary hMG have been produced since the 1980s, with the intention of eliminating most or all of the LH, such as a form with a 3:1 proportion ratio between follicle stimulating hormone (FSH) and LH, as well as a form resulting in the removal of almost all of the LH, the 'pure' urinary FSH. Finally, in the mid-1990s, recombinant pure FSH was produced in vitro from hamster ovarian cell cultures. The theoretical basis for the broad use of pure urinary FSH and recombinant FSH is that the very low endogenous LH levels after pituitary desensitization are sufficient for proper theca steroidogenesis; still, data in the literature and clinical experience may be controversial upon that issue. From the clinical point of view, clinicians nowadays tend to stimulate polycystic ovary syndrome patients with recombinant FSH plus the application of GnRH analogs in a long protocol. However, in poor responders, patients in whom ovulation is resistant to clomiphene citrate, those older than 40 years or hypergonadotropic patients with ovarian failure, urinary hMG, because endogenous LH levels are obviously not sufficient for proper steroidogenesis in the theca cells of the follicles of these patients, is necessary in add to the administration of GnRH analogs in a short or ultra-short protocol. Regarding normogonadotropic women (the majority of patients), most authors agree with the long-protocol application of GnRH analogs. In these patients, it is not certain whether recombinant FSH alone is sufficient for the best possible induction or whether exogenous LH administration in the form of urinary hMG still remains necessary." @default.
• W2000566236 created "2016-06-24" @default.
• W2000566236 creator A5055476440 @default.
• W2000566236 creator A5075138403 @default.
• W2000566236 creator A5083886109 @default.
• W2000566236 date "2000-01-01" @default.
• W2000566236 modified "2023-09-27" @default.
• W2000566236 title "The role of gonadotropins in follicular development and their use in ovulation induction protocols for assisted reproduction" @default.
• W2000566236 cites W155605848 @default.
• W2000566236 cites W1912510472 @default.
• W2000566236 cites W1971932969 @default.
• W2000566236 cites W1976088671 @default.
• W2000566236 cites W1979520020 @default.
• W2000566236 cites W1982596995 @default.
• W2000566236 cites W1988549211 @default.
• W2000566236 cites W1998370739 @default.
• W2000566236 cites W2002077649 @default.
• W2000566236 cites W2004337058 @default.
• W2000566236 cites W2041426853 @default.
• W2000566236 cites W2042648506 @default.
• W2000566236 cites W2047809422 @default.
• W2000566236 cites W2049393779 @default.
• W2000566236 cites W2054085421 @default.
• W2000566236 cites W2061107904 @default.
• W2000566236 cites W2072224637 @default.
• W2000566236 cites W2082616662 @default.
• W2000566236 cites W2087390463 @default.
• W2000566236 cites W2093034915 @default.
• W2000566236 cites W2100938534 @default.
• W2000566236 cites W2113313069 @default.
• W2000566236 cites W2119320692 @default.
• W2000566236 cites W2124297003 @default.
• W2000566236 cites W2130134811 @default.
• W2000566236 cites W2132265062 @default.
• W2000566236 cites W2150368787 @default.
• W2000566236 cites W2150504065 @default.
• W2000566236 cites W2256513898 @default.
• W2000566236 cites W2265528802 @default.
• W2000566236 cites W2271514294 @default.
• W2000566236 cites W2272432315 @default.
• W2000566236 cites W2285450843 @default.
• W2000566236 cites W2337190837 @default.
• W2000566236 cites W2395082718 @default.
• W2000566236 cites W2398788332 @default.
• W2000566236 cites W2417279551 @default.
• W2000566236 cites W2419114387 @default.
• W2000566236 cites W2419553274 @default.
• W2000566236 cites W2586245737 @default.
• W2000566236 cites W4206045940 @default.
• W2000566236 cites W4243764861 @default.
• W2000566236 doi "https://doi.org/10.1080/13625180008500389" @default.
• W2000566236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10943580" @default.
• W2000566236 hasPublicationYear "2000" @default.
• W2000566236 type Work @default.
• W2000566236 sameAs 2000566236 @default.
• W2000566236 citedByCount "23" @default.
• W2000566236 countsByYear W20005662362012 @default.
• W2000566236 countsByYear W20005662362013 @default.
• W2000566236 countsByYear W20005662362014 @default.
• W2000566236 countsByYear W20005662362015 @default.
• W2000566236 countsByYear W20005662362016 @default.
• W2000566236 countsByYear W20005662362017 @default.
• W2000566236 countsByYear W20005662362018 @default.
• W2000566236 countsByYear W20005662362021 @default.
• W2000566236 countsByYear W20005662362022 @default.
• W2000566236 crossrefType "journal-article" @default.
• W2000566236 hasAuthorship W2000566236A5055476440 @default.
• W2000566236 hasAuthorship W2000566236A5075138403 @default.
• W2000566236 hasAuthorship W2000566236A5083886109 @default.
• W2000566236 hasConcept C126322002 @default.
• W2000566236 hasConcept C134018914 @default.
• W2000566236 hasConcept C187785154 @default.
• W2000566236 hasConcept C2775948956 @default.
• W2000566236 hasConcept C2777391703 @default.
• W2000566236 hasConcept C2777702977 @default.
• W2000566236 hasConcept C2778575703 @default.
• W2000566236 hasConcept C2778782382 @default.
• W2000566236 hasConcept C2779234561 @default.
• W2000566236 hasConcept C2779306644 @default.
• W2000566236 hasConcept C2781230225 @default.
• W2000566236 hasConcept C2909827854 @default.
• W2000566236 hasConcept C29456083 @default.
• W2000566236 hasConcept C3018442814 @default.
• W2000566236 hasConcept C54355233 @default.
• W2000566236 hasConcept C71315377 @default.
• W2000566236 hasConcept C71924100 @default.
• W2000566236 hasConcept C86803240 @default.
• W2000566236 hasConceptScore W2000566236C126322002 @default.
• W2000566236 hasConceptScore W2000566236C134018914 @default.
• W2000566236 hasConceptScore W2000566236C187785154 @default.
• W2000566236 hasConceptScore W2000566236C2775948956 @default.
• W2000566236 hasConceptScore W2000566236C2777391703 @default.
• W2000566236 hasConceptScore W2000566236C2777702977 @default.
• W2000566236 hasConceptScore W2000566236C2778575703 @default.
• W2000566236 hasConceptScore W2000566236C2778782382 @default.
• W2000566236 hasConceptScore W2000566236C2779234561 @default.
• W2000566236 hasConceptScore W2000566236C2779306644 @default.
• W2000566236 hasConceptScore W2000566236C2781230225 @default.

• next