Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000566644> ?p ?o ?g. }
- W2000566644 endingPage "160" @default.
- W2000566644 startingPage "146" @default.
- W2000566644 abstract "We sought to examine AMPA receptor (AMPAR) function in the medial posterodorsal amygdala (MePD), as glutamate neurotransmission is critical for the neural response to vaginal-cervical stimulation that initiates pregnancy or pseudopregnancy. Female rats were infused with the AMPAR antagonist CNQX or vehicle directly into the MePD via bilaterally implanted cannulae, then either returned to their homecage (HC), or received 15 mounts-without-intromissions (MO) or 15 intromissions (15I) from a male. Expression of the activity marker EGR-1 was used to determine the CNQX concentration which would prevent mating-induced activation of MePD neurons. Separate cannulated females received CNQX infusions into the MePD prior to receiving 15I, and the oestrous cycle length was monitored by daily vaginal lavages. Infusion of CNQX (500 nm) blocked mating-induced neural activation and lengthened the oestrous cycle, demonstrating AMPAR involvement in the formation of pseudopregnancy. To further explore this involvement, separate groups of 15I, MO and HC females were killed 90 min or 3 h after testing treatment. Brain sections were immunolabeled for AMPAR-subunit GluR1 phosphorylated at one of two sites (Serine-831 or Serine-845), or total GluR1 and GluR2, and immunofluorescence intensity was measured in the MePD, hippocampus and hypothalamus. A mating-induced increase in Serine-831 phosphorylation after 3 h was observed only in the MePD, whereas there was no effect on Serine-845 phosphorylation. Additionally, we observed a time-dependent increase in total GluR1 staining intensity. These results suggest an increased AMPAR function in the MePD after receipt of VCS, and a role for AMPAR in the neural response to VCS resulting in pseudopregnancy." @default.
- W2000566644 created "2016-06-24" @default.
- W2000566644 creator A5010496812 @default.
- W2000566644 creator A5018615759 @default.
- W2000566644 creator A5033125519 @default.
- W2000566644 creator A5076249045 @default.
- W2000566644 date "2008-12-22" @default.
- W2000566644 modified "2023-10-10" @default.
- W2000566644 title "AMPA receptors in the medial amygdala are critical for establishing a neuroendocrine memory in the female rat" @default.
- W2000566644 cites W1487998758 @default.
- W2000566644 cites W1508977838 @default.
- W2000566644 cites W1573422440 @default.
- W2000566644 cites W1661693463 @default.
- W2000566644 cites W173488229 @default.
- W2000566644 cites W1834035763 @default.
- W2000566644 cites W1847283089 @default.
- W2000566644 cites W1851730414 @default.
- W2000566644 cites W1965409252 @default.
- W2000566644 cites W1975786395 @default.
- W2000566644 cites W1977077283 @default.
- W2000566644 cites W1977313055 @default.
- W2000566644 cites W1978155331 @default.
- W2000566644 cites W1979047018 @default.
- W2000566644 cites W1979586675 @default.
- W2000566644 cites W1981563555 @default.
- W2000566644 cites W1983252720 @default.
- W2000566644 cites W1983487457 @default.
- W2000566644 cites W1986010863 @default.
- W2000566644 cites W1986120363 @default.
- W2000566644 cites W1988387688 @default.
- W2000566644 cites W1989860867 @default.
- W2000566644 cites W1993135690 @default.
- W2000566644 cites W1998392208 @default.
- W2000566644 cites W1999393696 @default.
- W2000566644 cites W2000563504 @default.
- W2000566644 cites W2000926076 @default.
- W2000566644 cites W2003432290 @default.
- W2000566644 cites W2003900252 @default.
- W2000566644 cites W2010801556 @default.
- W2000566644 cites W2011893543 @default.
- W2000566644 cites W2011936972 @default.
- W2000566644 cites W2012995243 @default.
- W2000566644 cites W2015300991 @default.
- W2000566644 cites W2015387797 @default.
- W2000566644 cites W2016126067 @default.
- W2000566644 cites W2018072378 @default.
- W2000566644 cites W2019035666 @default.
- W2000566644 cites W2020143092 @default.
- W2000566644 cites W2020778578 @default.
- W2000566644 cites W2024969705 @default.
- W2000566644 cites W2027248555 @default.
- W2000566644 cites W2027436298 @default.
- W2000566644 cites W2028065219 @default.
- W2000566644 cites W2028170223 @default.
- W2000566644 cites W2030126027 @default.
- W2000566644 cites W2030816469 @default.
- W2000566644 cites W2032594882 @default.
- W2000566644 cites W2032822829 @default.
- W2000566644 cites W2035076944 @default.
- W2000566644 cites W2036240260 @default.
- W2000566644 cites W2042774531 @default.
- W2000566644 cites W2044150847 @default.
- W2000566644 cites W2047439767 @default.
- W2000566644 cites W2051209680 @default.
- W2000566644 cites W2053075927 @default.
- W2000566644 cites W2053651900 @default.
- W2000566644 cites W2054888976 @default.
- W2000566644 cites W2067883893 @default.
- W2000566644 cites W2074385487 @default.
- W2000566644 cites W2077776190 @default.
- W2000566644 cites W2078019698 @default.
- W2000566644 cites W2081390860 @default.
- W2000566644 cites W2082447865 @default.
- W2000566644 cites W2084998600 @default.
- W2000566644 cites W2085320839 @default.
- W2000566644 cites W2087100892 @default.
- W2000566644 cites W2090954164 @default.
- W2000566644 cites W2102170165 @default.
- W2000566644 cites W2105174239 @default.
- W2000566644 cites W2107766774 @default.
- W2000566644 cites W2114121049 @default.
- W2000566644 cites W2119001177 @default.
- W2000566644 cites W2119280578 @default.
- W2000566644 cites W2133623572 @default.
- W2000566644 cites W2138882887 @default.
- W2000566644 cites W2138913204 @default.
- W2000566644 cites W2146973655 @default.
- W2000566644 cites W2154912990 @default.
- W2000566644 cites W2162101917 @default.
- W2000566644 cites W2166978025 @default.
- W2000566644 cites W2168319429 @default.
- W2000566644 cites W2170532212 @default.
- W2000566644 cites W2416984069 @default.
- W2000566644 cites W2417785691 @default.
- W2000566644 cites W4231167673 @default.
- W2000566644 cites W4233643243 @default.
- W2000566644 cites W4244382469 @default.
- W2000566644 cites W4246659915 @default.