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- W2000568095 abstract "Delayed Wallerian degeneration after neuronal injury is a feature of the C57BL/Wlds mouse mutant. In the present study, we examined the effect of unilateral controlled cortical impact (CCI) on motor and cognitive performance in C57BL/6 and C57BL/Wlds mice. Performance on a beam-walking task was impaired in both injured groups over the first 3 weeks; however, between 28 and 35 days post injury, C57BL/6 mice continued to improve whereas C57BL/Wlds mice showed increased footfaults. In a spatial learning task, C57BL/Wlds animals performed consistently better than C57BL/6 mice when tested 7–10 days and 14–17 days following CCI. C57BL/Wlds mice also demonstrated improved working memory performance as compared with C57BL/6 mice when trained on days 21–22 after injury; this effect was lost on days 23 and 24, and was not evident in other animals tested in the same task at 28–31 days following injury. These results indicate a marked delay in motor and cognitive impairment following CCI in C57BL/Wlds mice compared with injured C57BL/6 controls. This is consistent with previous work showing delayed temporal evolution of neuronal degeneration in C57BL/Wlds mice and suggests CCI may be a suitable model for examining the functional consequences of traumatic brain injury (TBI) in genetically altered mice. J. Neurosci. Res. 53:718–727, 1998. © 1998 Wiley-Liss, Inc." @default.
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- W2000568095 date "1998-09-15" @default.
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- W2000568095 title "Traumatic brain injury causes delayed motor and cognitive impairment in a mutant mouse strain known to exhibit delayed wallerian degeneration" @default.
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- W2000568095 doi "https://doi.org/10.1002/(sici)1097-4547(19980915)53:6<718::aid-jnr9>3.0.co;2-8" @default.
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