FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000568327> ?p ?o ?g. }

• W2000568327 endingPage "608" @default.
• W2000568327 startingPage "598" @default.
• W2000568327 abstract "BACKGROUND Although there are many factors that might contribute to tissue injury during ischemia and reperfusion, the loss of adenine nucleotides has long been considered to be of importance. This has led to the study of interventions designed to limit the loss of nucleotides or to enhance the rate of nucleotide resynthesis during reperfusion. Alternatively, the breakdown of adenosine triphosphate to adenosine might represent a protective response of the ischemic heart because adenosine is considered an anti-injury autocoid. Augmentation of endogenous adenosine levels might be beneficial. For these reasons, the protective properties of acadesine (AICAr: 5-amino-4-imidazole carboxamide riboside) were assessed in a rat model of myocardial ischemia and reperfusion. METHODS AND RESULTS The protective properties of acadesine were studied in the isolated, perfused rat heart subjected to global hypothermic (20 degrees C) ischemia and reperfusion. When acadesine was given as an in vivo pretreatment (100 mg/kg i.v. 15 minutes before study) followed by being administered as an additive (20 mumol/l) to the St. Thomas' Hospital cardioplegic solution (single dose) and then as an additive (20 mumol/l) to the initial reperfusion (15 minutes) solution, the recovery of aortic flow after 2.5 hours of ischemia was improved from its control value of 16.5 +/- 3.9 ml/min to 28.9 +/- 4.1 ml/min (n = 8 per group; p less than 0.05). Similar protection was seen with other indexes of cardiac function. Analysis of hearts obtained at the end of 2.5 hours of ischemia and 35 minutes of reperfusion revealed no significant differences in metabolite content between control and drug-treated hearts with the exception of inosine monophosphate, which was increased from its drug-free control value of 0.10 +/- 0.01 mumol/g dry wt to 0.86 +/- 0.06 mumol/g dry wt (p less than 0.05). In further studies (n = 8 per group), with multidose (every 30 minutes) cardioplegia and extended periods (6 hours) of hypothermic ischemia, acadesine consistently led to higher mean recoveries of function and lower levels of creatine kinase leakage. Again, the only significant metabolic effect was an increase in tissue inosine monophosphate content. In studies (n = 12 per group) to determine whether acadesine was acting before, during, or after ischemia, the drug was given 1) only as pretreatment (100 mg/kg i.v.), 2) only during single-dose cardioplegia (20 mumol/l), or 3) only during reperfusion (20 mumol/l). Significant protection was observed in the first two groups (recovery of aortic flow increased from 10.6 +/- 2.6 ml/min in the acadesine-free control to 22.6 +/- 2.8 and 23.6 +/- 3.1 ml/min, respectively; p less than 0.05). No significant protection was observed when acadesine was given only during reperfusion. In dose-response studies, acadesine (0, 5, 20, 50, 200, and 1,000 mumol/l; n = 12 per group) was given only as a cardioplegic additive; the postischemic recoveries of aortic flow were 15.4 +/- 2.8, 16.9 +/- 3.6, 29.5 +/- 3.8, 27.4 +/- 3.8, 26.7 +/- 4.2, and 27.1 +/- 2.7 ml/min, respectively. CONCLUSIONS Acadesine improves the ability of the heart to recover from ischemia and reperfusion when administered before ischemia or with cardioplegia. The mechanism underlying the protection remains to be resolved." @default.
• W2000568327 created "2016-06-24" @default.
• W2000568327 creator A5027440693 @default.
• W2000568327 creator A5048605328 @default.
• W2000568327 creator A5049153704 @default.
• W2000568327 creator A5088168779 @default.
• W2000568327 date "1992-08-01" @default.
• W2000568327 modified "2023-09-27" @default.
• W2000568327 title "Acadesine and myocardial protection. Studies of time of administration and dose-response relations in the rat." @default.
• W2000568327 cites W1228007247 @default.
• W2000568327 cites W1584816909 @default.
• W2000568327 cites W1936372361 @default.
• W2000568327 cites W1973772383 @default.
• W2000568327 cites W1997502768 @default.
• W2000568327 cites W2037475835 @default.
• W2000568327 cites W2048405568 @default.
• W2000568327 cites W2058656681 @default.
• W2000568327 cites W2067075110 @default.
• W2000568327 cites W2073702336 @default.
• W2000568327 cites W2074822093 @default.
• W2000568327 cites W2075206212 @default.
• W2000568327 cites W2162250764 @default.
• W2000568327 cites W2335088247 @default.
• W2000568327 cites W2410699849 @default.
• W2000568327 cites W2410892011 @default.
• W2000568327 cites W2411117828 @default.
• W2000568327 cites W2412797212 @default.
• W2000568327 cites W2413420932 @default.
• W2000568327 cites W2418297939 @default.
• W2000568327 cites W2432195370 @default.
• W2000568327 cites W2443206173 @default.
• W2000568327 cites W2994711796 @default.
• W2000568327 cites W57252275 @default.
• W2000568327 doi "https://doi.org/10.1161/01.cir.86.2.598" @default.
• W2000568327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1638725" @default.
• W2000568327 hasPublicationYear "1992" @default.
• W2000568327 type Work @default.
• W2000568327 sameAs 2000568327 @default.
• W2000568327 citedByCount "53" @default.
• W2000568327 countsByYear W20005683272012 @default.
• W2000568327 countsByYear W20005683272014 @default.
• W2000568327 countsByYear W20005683272015 @default.
• W2000568327 countsByYear W20005683272016 @default.
• W2000568327 countsByYear W20005683272017 @default.
• W2000568327 countsByYear W20005683272020 @default.
• W2000568327 countsByYear W20005683272021 @default.
• W2000568327 crossrefType "journal-article" @default.
• W2000568327 hasAuthorship W2000568327A5027440693 @default.
• W2000568327 hasAuthorship W2000568327A5048605328 @default.
• W2000568327 hasAuthorship W2000568327A5049153704 @default.
• W2000568327 hasAuthorship W2000568327A5088168779 @default.
• W2000568327 hasBestOaLocation W20005683271 @default.
• W2000568327 hasConcept C104317684 @default.
• W2000568327 hasConcept C126322002 @default.
• W2000568327 hasConcept C150903083 @default.
• W2000568327 hasConcept C185592680 @default.
• W2000568327 hasConcept C207001950 @default.
• W2000568327 hasConcept C2776991684 @default.
• W2000568327 hasConcept C2779676291 @default.
• W2000568327 hasConcept C2780114680 @default.
• W2000568327 hasConcept C2994266630 @default.
• W2000568327 hasConcept C42219234 @default.
• W2000568327 hasConcept C512185932 @default.
• W2000568327 hasConcept C541997718 @default.
• W2000568327 hasConcept C55493867 @default.
• W2000568327 hasConcept C71924100 @default.
• W2000568327 hasConcept C86803240 @default.
• W2000568327 hasConcept C98274493 @default.
• W2000568327 hasConceptScore W2000568327C104317684 @default.
• W2000568327 hasConceptScore W2000568327C126322002 @default.
• W2000568327 hasConceptScore W2000568327C150903083 @default.
• W2000568327 hasConceptScore W2000568327C185592680 @default.
• W2000568327 hasConceptScore W2000568327C207001950 @default.
• W2000568327 hasConceptScore W2000568327C2776991684 @default.
• W2000568327 hasConceptScore W2000568327C2779676291 @default.
• W2000568327 hasConceptScore W2000568327C2780114680 @default.
• W2000568327 hasConceptScore W2000568327C2994266630 @default.
• W2000568327 hasConceptScore W2000568327C42219234 @default.
• W2000568327 hasConceptScore W2000568327C512185932 @default.
• W2000568327 hasConceptScore W2000568327C541997718 @default.
• W2000568327 hasConceptScore W2000568327C55493867 @default.
• W2000568327 hasConceptScore W2000568327C71924100 @default.
• W2000568327 hasConceptScore W2000568327C86803240 @default.
• W2000568327 hasConceptScore W2000568327C98274493 @default.
• W2000568327 hasIssue "2" @default.
• W2000568327 hasLocation W20005683271 @default.
• W2000568327 hasLocation W20005683272 @default.
• W2000568327 hasOpenAccess W2000568327 @default.
• W2000568327 hasPrimaryLocation W20005683271 @default.
• W2000568327 hasRelatedWork W14376166 @default.
• W2000568327 hasRelatedWork W1986466549 @default.
• W2000568327 hasRelatedWork W1995812817 @default.
• W2000568327 hasRelatedWork W2032354327 @default.
• W2000568327 hasRelatedWork W2065337698 @default.
• W2000568327 hasRelatedWork W2085134341 @default.
• W2000568327 hasRelatedWork W2107555224 @default.
• W2000568327 hasRelatedWork W2131346251 @default.
• W2000568327 hasRelatedWork W2609160282 @default.

• next