FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000570774> ?p ?o ?g. }

• W2000570774 endingPage "939" @default.
• W2000570774 startingPage "926" @default.
• W2000570774 abstract "Thyroid hormones have a profound influence on human development and disease. The hypothalamic-pituitary-thyroid axis involves finely tuned feedback mechanisms to maintain thyroid hormone (TH) levels. Despite the important role of TH-negative feedback in regulating this axis, the mechanism by which this occurs is not clearly defined. Previous in vivo studies suggest separate roles for the two thyroid hormone receptor isoforms, THRA and THRB, in this axis. We performed studies using a unique pituitary thyrotroph cell line (TαT1.1) to determine the relative roles of THRA and THRB in the regulation of Tshb. Using chromatin immunoprecipitation assays, we found that THRB, not THRA, bound to the Tshb promoter. By selectively depleting THRB, THRA, or both THRA and THRB in TαT1.1 cells, we found that simultaneous knockdown of both THRB and THRA abolished T3-mediated down-regulation of Tshb at concentrations as high as 100 nm T3. In contrast, THRA knockdown alone had no effect on T3-negative regulation, whereas THRB knockdown alone abolished T3-mediated down-regulation of Tshb mRNA levels at 10 nm but not 100 nm T3 concentrations. Interestingly, chromatin immunoprecipitation assays showed that THRA becomes enriched on the Tshb promoter after knockdown of THRB. Thus, a likely mechanism for the differential effects of THR isoforms on Tshb may be based on their differential DNA-binding affinity to the promoter." @default.
• W2000570774 created "2016-06-24" @default.
• W2000570774 creator A5002248611 @default.
• W2000570774 creator A5010366700 @default.
• W2000570774 creator A5026510958 @default.
• W2000570774 creator A5049313563 @default.
• W2000570774 creator A5051301505 @default.
• W2000570774 creator A5051458869 @default.
• W2000570774 creator A5081334012 @default.
• W2000570774 date "2012-06-01" @default.
• W2000570774 modified "2023-10-18" @default.
• W2000570774 title "Fundamentally Distinct Roles of Thyroid Hormone Receptor Isoforms in a Thyrotroph Cell Line Are due to Differential DNA Binding" @default.
• W2000570774 cites W1486845435 @default.
• W2000570774 cites W1517784889 @default.
• W2000570774 cites W1520441844 @default.
• W2000570774 cites W1547233041 @default.
• W2000570774 cites W1556768294 @default.
• W2000570774 cites W1881800315 @default.
• W2000570774 cites W1966269969 @default.
• W2000570774 cites W1971263640 @default.
• W2000570774 cites W1972473911 @default.
• W2000570774 cites W1973812900 @default.
• W2000570774 cites W1975951308 @default.
• W2000570774 cites W1976347138 @default.
• W2000570774 cites W1976454625 @default.
• W2000570774 cites W1979869334 @default.
• W2000570774 cites W1980577578 @default.
• W2000570774 cites W1988616355 @default.
• W2000570774 cites W1995347382 @default.
• W2000570774 cites W2000303521 @default.
• W2000570774 cites W2011990607 @default.
• W2000570774 cites W2014183412 @default.
• W2000570774 cites W2015795642 @default.
• W2000570774 cites W2020626851 @default.
• W2000570774 cites W2021932599 @default.
• W2000570774 cites W2031669450 @default.
• W2000570774 cites W2033340209 @default.
• W2000570774 cites W2034211351 @default.
• W2000570774 cites W2037312424 @default.
• W2000570774 cites W2039320951 @default.
• W2000570774 cites W2043008819 @default.
• W2000570774 cites W2046094921 @default.
• W2000570774 cites W2046456353 @default.
• W2000570774 cites W2046829538 @default.
• W2000570774 cites W2047332277 @default.
• W2000570774 cites W2057348494 @default.
• W2000570774 cites W2059695404 @default.
• W2000570774 cites W2076376728 @default.
• W2000570774 cites W2077520670 @default.
• W2000570774 cites W2082283713 @default.
• W2000570774 cites W2085205986 @default.
• W2000570774 cites W2091671221 @default.
• W2000570774 cites W2107277218 @default.
• W2000570774 cites W2108865564 @default.
• W2000570774 cites W2115417856 @default.
• W2000570774 cites W2115782929 @default.
• W2000570774 cites W2117825435 @default.
• W2000570774 cites W2142640185 @default.
• W2000570774 cites W2151212381 @default.
• W2000570774 cites W2170143324 @default.
• W2000570774 cites W33723193 @default.
• W2000570774 cites W4210406638 @default.
• W2000570774 doi "https://doi.org/10.1210/me.2011-1290" @default.
• W2000570774 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3355539" @default.
• W2000570774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22570333" @default.
• W2000570774 hasPublicationYear "2012" @default.
• W2000570774 type Work @default.
• W2000570774 sameAs 2000570774 @default.
• W2000570774 citedByCount "44" @default.
• W2000570774 countsByYear W20005707742013 @default.
• W2000570774 countsByYear W20005707742014 @default.
• W2000570774 countsByYear W20005707742015 @default.
• W2000570774 countsByYear W20005707742016 @default.
• W2000570774 countsByYear W20005707742017 @default.
• W2000570774 countsByYear W20005707742018 @default.
• W2000570774 countsByYear W20005707742019 @default.
• W2000570774 countsByYear W20005707742020 @default.
• W2000570774 countsByYear W20005707742023 @default.
• W2000570774 crossrefType "journal-article" @default.
• W2000570774 hasAuthorship W2000570774A5002248611 @default.
• W2000570774 hasAuthorship W2000570774A5010366700 @default.
• W2000570774 hasAuthorship W2000570774A5026510958 @default.
• W2000570774 hasAuthorship W2000570774A5049313563 @default.
• W2000570774 hasAuthorship W2000570774A5051301505 @default.
• W2000570774 hasAuthorship W2000570774A5051458869 @default.
• W2000570774 hasAuthorship W2000570774A5081334012 @default.
• W2000570774 hasBestOaLocation W20005707741 @default.
• W2000570774 hasConcept C101762097 @default.
• W2000570774 hasConcept C104317684 @default.
• W2000570774 hasConcept C109115496 @default.
• W2000570774 hasConcept C126322002 @default.
• W2000570774 hasConcept C134018914 @default.
• W2000570774 hasConcept C134320426 @default.
• W2000570774 hasConcept C150194340 @default.
• W2000570774 hasConcept C173396325 @default.
• W2000570774 hasConcept C526584372 @default.
• W2000570774 hasConcept C54355233 @default.
• W2000570774 hasConcept C71315377 @default.

• next