Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000570809> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2000570809 endingPage "S51" @default.
- W2000570809 startingPage "S51" @default.
- W2000570809 abstract "The mechanism of action of nitrates, compounds that have been used classically in the treatment of heart failure, appears to be the stimulation of guanylate cyclase in vascular smooth muscle, perhaps the same physiologic action as endothelium-derived relaxing factor, now thought to be synonymous with nitric oxide (NO). Drugs that release NO either inside cells or in plasma have been developed recently. One such compound, CAS 936, when taken orally, is converted to an active metabolite, 3754. The goal of our studies was to determine the effects of CAS 936 and 3754 on cardiovascular function in conscious dogs before and after the development of pacing-induced heart failure. CAS 936 (10 mg/kg, p.o.) increased large coronary artery diameter 9.1 +/- 1.2% and reduced left ventricular end diastolic pressure (LVEDP) 2.5 +/- 0.5 mm Hg, but had no significant effects on coronary blood flow or vascular resistance. The metabolite 3754 caused dose-related increases in coronary artery diameter, and large reductions in LVEDP. The effect of these compounds on large coronary artery diameter was significantly greater (p < 0.05) than that of nitroglycerin (25 micrograms/kg). After heart failure, both CAS 936 and 3754 caused significant increases in large coronary artery diameter (10%) and a reduction in preload, up to 10 mm Hg, which was even larger than in normal dogs. Thus, these NO-releasing agents are potent selective large-vessel dilators that also reduce preload and maintain this unique vasodilator profile even in the failing heart." @default.
- W2000570809 created "2016-06-24" @default.
- W2000570809 creator A5049626281 @default.
- W2000570809 creator A5051439028 @default.
- W2000570809 creator A5059142291 @default.
- W2000570809 creator A5060738336 @default.
- W2000570809 creator A5075877965 @default.
- W2000570809 creator A5082549212 @default.
- W2000570809 creator A5083216340 @default.
- W2000570809 date "1993-01-01" @default.
- W2000570809 modified "2023-09-27" @default.
- W2000570809 title "Effects of an Orally Active NO-Releasing Agent, CAS 936, and Its Active Metabolite, 3754, on Cardiac and Coronary Dynamics in Normal Conscious Dogs and After Pacing-Induced Heart Failure" @default.
- W2000570809 doi "https://doi.org/10.1097/00005344-199300221-00010" @default.
- W2000570809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7504769" @default.
- W2000570809 hasPublicationYear "1993" @default.
- W2000570809 type Work @default.
- W2000570809 sameAs 2000570809 @default.
- W2000570809 citedByCount "15" @default.
- W2000570809 countsByYear W20005708092016 @default.
- W2000570809 countsByYear W20005708092022 @default.
- W2000570809 crossrefType "journal-article" @default.
- W2000570809 hasAuthorship W2000570809A5049626281 @default.
- W2000570809 hasAuthorship W2000570809A5051439028 @default.
- W2000570809 hasAuthorship W2000570809A5059142291 @default.
- W2000570809 hasAuthorship W2000570809A5060738336 @default.
- W2000570809 hasAuthorship W2000570809A5075877965 @default.
- W2000570809 hasAuthorship W2000570809A5082549212 @default.
- W2000570809 hasAuthorship W2000570809A5083216340 @default.
- W2000570809 hasBestOaLocation W20005708091 @default.
- W2000570809 hasConcept C120770815 @default.
- W2000570809 hasConcept C126322002 @default.
- W2000570809 hasConcept C149151106 @default.
- W2000570809 hasConcept C158846371 @default.
- W2000570809 hasConcept C164705383 @default.
- W2000570809 hasConcept C178853913 @default.
- W2000570809 hasConcept C185592680 @default.
- W2000570809 hasConcept C2776820930 @default.
- W2000570809 hasConcept C2777477808 @default.
- W2000570809 hasConcept C2778198053 @default.
- W2000570809 hasConcept C48277249 @default.
- W2000570809 hasConcept C519581460 @default.
- W2000570809 hasConcept C71924100 @default.
- W2000570809 hasConcept C84393581 @default.
- W2000570809 hasConceptScore W2000570809C120770815 @default.
- W2000570809 hasConceptScore W2000570809C126322002 @default.
- W2000570809 hasConceptScore W2000570809C149151106 @default.
- W2000570809 hasConceptScore W2000570809C158846371 @default.
- W2000570809 hasConceptScore W2000570809C164705383 @default.
- W2000570809 hasConceptScore W2000570809C178853913 @default.
- W2000570809 hasConceptScore W2000570809C185592680 @default.
- W2000570809 hasConceptScore W2000570809C2776820930 @default.
- W2000570809 hasConceptScore W2000570809C2777477808 @default.
- W2000570809 hasConceptScore W2000570809C2778198053 @default.
- W2000570809 hasConceptScore W2000570809C48277249 @default.
- W2000570809 hasConceptScore W2000570809C519581460 @default.
- W2000570809 hasConceptScore W2000570809C71924100 @default.
- W2000570809 hasConceptScore W2000570809C84393581 @default.
- W2000570809 hasIssue "Suppl. 7" @default.
- W2000570809 hasLocation W20005708091 @default.
- W2000570809 hasLocation W20005708092 @default.
- W2000570809 hasLocation W20005708093 @default.
- W2000570809 hasOpenAccess W2000570809 @default.
- W2000570809 hasPrimaryLocation W20005708091 @default.
- W2000570809 hasRelatedWork W133119128 @default.
- W2000570809 hasRelatedWork W1804176621 @default.
- W2000570809 hasRelatedWork W1999929948 @default.
- W2000570809 hasRelatedWork W2000570809 @default.
- W2000570809 hasRelatedWork W2038658388 @default.
- W2000570809 hasRelatedWork W2072803364 @default.
- W2000570809 hasRelatedWork W2399679950 @default.
- W2000570809 hasRelatedWork W4229855894 @default.
- W2000570809 hasRelatedWork W4366128525 @default.
- W2000570809 hasRelatedWork W1715491286 @default.
- W2000570809 hasVolume "22" @default.
- W2000570809 isParatext "false" @default.
- W2000570809 isRetracted "false" @default.
- W2000570809 magId "2000570809" @default.
- W2000570809 workType "article" @default.