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• W2000571421 endingPage "873" @default.
• W2000571421 startingPage "866" @default.
• W2000571421 abstract "Lactobacillus casei I-5 isolated from an alcohol fermentation broth enhanced immunity and prevented pathogenic infection as a probiotic. Mice fed with I-5 cells for 11 days prior to an intraperitoneal challenge with pathogenic Escherichia coli Juhl exhibited a high survival rate compared with the control group. Rats fed with I-5 cells for 10 days significantly increased the phagocytosis of peritoneal macrophages. In a cell culture system employing peritoneal macrophages from rats, the I-5 administration activated NF-kappaB stimulated by LPS. It also enhanced LPS-stimulated IL-12 and TNF-alpha production, but not IL-6 production. These results show that L. casei I-5 effectively prevented infection by pathogenic E. coli possibly through the activation of peritoneal macrophages. The strain would be useful to prevent pathogenic microbial infections in humans and farm animals." @default.
• W2000571421 created "2016-06-24" @default.
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• W2000571421 date "2007-04-23" @default.
• W2000571421 modified "2023-10-18" @default.
• W2000571421 title "Prevention of Pathogenic<i>Escherichia coli</i>Infection in Mice and Stimulation of Macrophage Activation in Rats by an Oral Administration of Probiotic<i>Lactobacillus casei</i>I-5" @default.
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• W2000571421 doi "https://doi.org/10.1271/bbb.60464" @default.
• W2000571421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17420603" @default.
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