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• W2000571470 abstract "Neural networks in the spinal cord can generate locomotion in the absence of rhythmic input from higher brain structures or sensory feedback because they contain an intrinsic source of excitation. However, the molecular identity of the spinal interneurons underlying the excitatory drive within the locomotor circuit has remained unclear. Using optogenetics, we show that activation of a molecularly defined class of ipsilateral premotor interneurons elicits locomotion. These interneurons represent the excitatory module of the locomotor networks and are sufficient to produce a coordinated swimming pattern in zebrafish. They correspond to the V2a interneuron class and express the transcription factor Chx10. They produce sufficient excitatory drive within the spinal networks to generate coordinated locomotor activity. Therefore, our results define the V2a interneurons as the excitatory module within the spinal locomotor networks that is sufficient to initiate and maintain locomotor activity." @default.
• W2000571470 created "2016-06-24" @default.
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• W2000571470 date "2013-12-31" @default.
• W2000571470 modified "2023-10-15" @default.
• W2000571470 title "Optogenetic Activation of Excitatory Premotor Interneurons Is Sufficient to Generate Coordinated Locomotor Activity in Larval Zebrafish" @default.
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• W2000571470 doi "https://doi.org/10.1523/jneurosci.4087-13.2014" @default.
• W2000571470 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6608174" @default.
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