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- W2000571490 abstract "Candiduria has emerged as a common, vexing diagnostic and therapeutic problem over the past 40 years. Treatment by means of bladder irrigation with a solution of amphotericin B has become widely used in clinical practice. However, the specifics of the procedure—concentration of amphotericin B, use of continuous washing vs. instillation with cross-clamping to allow “dwell-times,” and duration of treatment—are based entirely on anecdotal experiences. The published reports and evolution of recommendations are reviewed. A prospective randomized double-blind study is needed to provide answers. In the meantime, administration of 200–300 mL of amphotericin B solution by triple-lumen urethral catheter with cross-clamping for 60–90 minutes seems most appropriate. Irrigation for no longer than 2 days should sufficeif the procedure is to be effective. The optimal concentration of amphotericin B has not been defined; however, 5–10 mg/L appears adequate." @default.
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- W2000571490 date "1993-01-01" @default.
- W2000571490 modified "2023-09-24" @default.
- W2000571490 title "The Enigma of Candiduria: Evolution of Bladder Irrigation with Amphotericin B for Management--From Anecdote to Dogma and a Lesson from Machiavelli" @default.
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- W2000571490 doi "https://doi.org/10.1093/clinids/16.1.145" @default.
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