FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000571801> ?p ?o ?g. }

• W2000571801 endingPage "649" @default.
• W2000571801 startingPage "642" @default.
• W2000571801 abstract "Initial studies of growth hormone (GH) replacement in adults used weight- and surface area-based dosing regimes extrapolated from paediatric practice. Much of the beneficial effects were pharmacological rather than physiological. Furthermore, weight-based dosing regimens resulted in lower overall doses in females who require approximately threefold greater GH secretion in health to maintain a similar insulin-like growth factor-I level to males. This inequality of dosing explains studies reporting that males respond more efficaciously to GH replacement. Recent studies individualising GH doses to normalize serum insulin-like growth factor-I level have shown a similar spectra of beneficial effects to earlier weight-based studies; however, the degree of these effects on biological sequelea was reduced. Using this individualised dosing regimen, both genders responded equally to GH replacement for most biological end-points. The effect of GH replacement on bone mineral content is complex, and is dependent on the onset of GH deficiency, age of the patient and dosing regimen. GH is increasingly recognized as being intricately involved in regulation of surrogate markers of vascular risk and endothelial dysfunction, replacement of which normalises these indices. Definitive data on the effect of GH on mortality is awaited. Studies of 5-10 years duration suggest that beneficial effects of GH are maintained long-term. A depot preparation of GH is currently under investigation and, if proven to be efficacious and safe, might be a more acceptable therapy to a proportion of patients." @default.
• W2000571801 created "2016-06-24" @default.
• W2000571801 creator A5053080840 @default.
• W2000571801 date "2003-12-01" @default.
• W2000571801 modified "2023-09-25" @default.
• W2000571801 title "Adult growth hormone replacement: current understanding" @default.
• W2000571801 cites W1968202701 @default.
• W2000571801 cites W1968997333 @default.
• W2000571801 cites W1970734380 @default.
• W2000571801 cites W1977519989 @default.
• W2000571801 cites W1982354909 @default.
• W2000571801 cites W1984487014 @default.
• W2000571801 cites W1985507827 @default.
• W2000571801 cites W1989278818 @default.
• W2000571801 cites W1990049523 @default.
• W2000571801 cites W1992872158 @default.
• W2000571801 cites W1997016561 @default.
• W2000571801 cites W1998010040 @default.
• W2000571801 cites W1999759703 @default.
• W2000571801 cites W2004290721 @default.
• W2000571801 cites W2012485610 @default.
• W2000571801 cites W2019361743 @default.
• W2000571801 cites W2020636054 @default.
• W2000571801 cites W2021667708 @default.
• W2000571801 cites W2021913459 @default.
• W2000571801 cites W2023206717 @default.
• W2000571801 cites W2027759979 @default.
• W2000571801 cites W2028938257 @default.
• W2000571801 cites W2034870004 @default.
• W2000571801 cites W2035638235 @default.
• W2000571801 cites W2050318024 @default.
• W2000571801 cites W2054250402 @default.
• W2000571801 cites W2055648105 @default.
• W2000571801 cites W2061736076 @default.
• W2000571801 cites W2061933206 @default.
• W2000571801 cites W2063701256 @default.
• W2000571801 cites W2065004245 @default.
• W2000571801 cites W2065218659 @default.
• W2000571801 cites W2067376123 @default.
• W2000571801 cites W2070865932 @default.
• W2000571801 cites W2072942478 @default.
• W2000571801 cites W2073256970 @default.
• W2000571801 cites W2080260830 @default.
• W2000571801 cites W2084612579 @default.
• W2000571801 cites W2086269626 @default.
• W2000571801 cites W2092794935 @default.
• W2000571801 cites W2095611917 @default.
• W2000571801 cites W2097442718 @default.
• W2000571801 cites W2100488282 @default.
• W2000571801 cites W2100532714 @default.
• W2000571801 cites W2101471112 @default.
• W2000571801 cites W2102030528 @default.
• W2000571801 cites W2105251665 @default.
• W2000571801 cites W2115314835 @default.
• W2000571801 cites W2116795137 @default.
• W2000571801 cites W2117350664 @default.
• W2000571801 cites W2119084562 @default.
• W2000571801 cites W2120108803 @default.
• W2000571801 cites W2126331664 @default.
• W2000571801 cites W2129855350 @default.
• W2000571801 cites W2132556560 @default.
• W2000571801 cites W2135982635 @default.
• W2000571801 cites W2137204745 @default.
• W2000571801 cites W2140469927 @default.
• W2000571801 cites W2140484477 @default.
• W2000571801 cites W2143643540 @default.
• W2000571801 cites W2145782010 @default.
• W2000571801 cites W2146352480 @default.
• W2000571801 cites W2153098217 @default.
• W2000571801 cites W2154414989 @default.
• W2000571801 cites W2154655952 @default.
• W2000571801 cites W2155234357 @default.
• W2000571801 cites W2155658977 @default.
• W2000571801 cites W2158211958 @default.
• W2000571801 cites W2160159332 @default.
• W2000571801 cites W2160823924 @default.
• W2000571801 cites W2161622680 @default.
• W2000571801 cites W2165169641 @default.
• W2000571801 cites W2166720830 @default.
• W2000571801 cites W2166983543 @default.
• W2000571801 cites W2166989721 @default.
• W2000571801 cites W2167403780 @default.
• W2000571801 cites W2169611533 @default.
• W2000571801 cites W2315987042 @default.
• W2000571801 cites W2331609610 @default.
• W2000571801 doi "https://doi.org/10.1016/j.coph.2003.07.008" @default.
• W2000571801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14644017" @default.
• W2000571801 hasPublicationYear "2003" @default.
• W2000571801 type Work @default.
• W2000571801 sameAs 2000571801 @default.
• W2000571801 citedByCount "7" @default.
• W2000571801 countsByYear W20005718012021 @default.
• W2000571801 crossrefType "journal-article" @default.
• W2000571801 hasAuthorship W2000571801A5053080840 @default.
• W2000571801 hasConcept C126322002 @default.
• W2000571801 hasConcept C134018914 @default.
• W2000571801 hasConcept C170493617 @default.
• W2000571801 hasConcept C2775960820 @default.

• next