Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000573492> ?p ?o ?g. }
- W2000573492 endingPage "1425" @default.
- W2000573492 startingPage "1411" @default.
- W2000573492 abstract "Patient derived xenograft (PDX) is defined as a growth of patients’ tumor in the xenograft setting. The evolution of cancer model in animal has a century old history. The most single reason that exerted the pressure on the traditional animal model of cancer to evolve to PDX is that the traditional models have not delivered as expected and traditional models have not predicted clinical success. In spite of well above 50 drugs developed and approved for oncology over the last several decades, there remains a nirking paucity of clinical success as a reminder that this war on cancer riding on the animal model is far from won. In a backbreaking attempt to analyze the failure, the limitation of the “model” system appeared to be the most rational cause of this shortcoming. It was more of a failure to test a drug rather than a failure to make a drug that stunted our collective growth and success in cancer research. PDX is the product of this age-old failure and its fitness is currently tested in virtually all organ-type solid tumors. This review will present and appraise PDX model in the context of its evolution, its future promise, its limitations and more specifically, the current content of PDX in different solid tumors including breast, lung, colorectal, prostrate, GBM, pancreatic, hepatocellular carcinoma and melanoma." @default.
- W2000573492 created "2016-06-24" @default.
- W2000573492 creator A5012509754 @default.
- W2000573492 creator A5030281378 @default.
- W2000573492 creator A5060185684 @default.
- W2000573492 creator A5065634508 @default.
- W2000573492 date "2013-01-01" @default.
- W2000573492 modified "2023-10-16" @default.
- W2000573492 title "Evolution of Tumor Model: From Animal Model of Tumor to Tumor Model in Animal" @default.
- W2000573492 cites W1803959510 @default.
- W2000573492 cites W1933870422 @default.
- W2000573492 cites W1966476566 @default.
- W2000573492 cites W1972793416 @default.
- W2000573492 cites W1972984645 @default.
- W2000573492 cites W1987443121 @default.
- W2000573492 cites W1989805762 @default.
- W2000573492 cites W1989832006 @default.
- W2000573492 cites W1992312579 @default.
- W2000573492 cites W1992514491 @default.
- W2000573492 cites W1998238577 @default.
- W2000573492 cites W2005706175 @default.
- W2000573492 cites W2005946855 @default.
- W2000573492 cites W2009164582 @default.
- W2000573492 cites W2012235549 @default.
- W2000573492 cites W2015184241 @default.
- W2000573492 cites W2015475396 @default.
- W2000573492 cites W2016349404 @default.
- W2000573492 cites W2019651806 @default.
- W2000573492 cites W2023447208 @default.
- W2000573492 cites W2024253911 @default.
- W2000573492 cites W2029336551 @default.
- W2000573492 cites W2029480581 @default.
- W2000573492 cites W2030752121 @default.
- W2000573492 cites W2031256553 @default.
- W2000573492 cites W2031840048 @default.
- W2000573492 cites W2039813669 @default.
- W2000573492 cites W2041718527 @default.
- W2000573492 cites W2061271065 @default.
- W2000573492 cites W2069399470 @default.
- W2000573492 cites W2081737065 @default.
- W2000573492 cites W2086716570 @default.
- W2000573492 cites W2096283457 @default.
- W2000573492 cites W2103258359 @default.
- W2000573492 cites W2109937560 @default.
- W2000573492 cites W2118421998 @default.
- W2000573492 cites W2118471405 @default.
- W2000573492 cites W2119092375 @default.
- W2000573492 cites W2131636566 @default.
- W2000573492 cites W2146041593 @default.
- W2000573492 cites W2151089236 @default.
- W2000573492 cites W2154698804 @default.
- W2000573492 cites W2158155247 @default.
- W2000573492 cites W2158811570 @default.
- W2000573492 cites W2159607376 @default.
- W2000573492 cites W2160947862 @default.
- W2000573492 cites W2161831994 @default.
- W2000573492 cites W2166311434 @default.
- W2000573492 cites W2166896388 @default.
- W2000573492 doi "https://doi.org/10.4236/jct.2013.49168" @default.
- W2000573492 hasPublicationYear "2013" @default.
- W2000573492 type Work @default.
- W2000573492 sameAs 2000573492 @default.
- W2000573492 citedByCount "5" @default.
- W2000573492 countsByYear W20005734922015 @default.
- W2000573492 countsByYear W20005734922016 @default.
- W2000573492 countsByYear W20005734922019 @default.
- W2000573492 countsByYear W20005734922021 @default.
- W2000573492 countsByYear W20005734922023 @default.
- W2000573492 crossrefType "journal-article" @default.
- W2000573492 hasAuthorship W2000573492A5012509754 @default.
- W2000573492 hasAuthorship W2000573492A5030281378 @default.
- W2000573492 hasAuthorship W2000573492A5060185684 @default.
- W2000573492 hasAuthorship W2000573492A5065634508 @default.
- W2000573492 hasBestOaLocation W20005734921 @default.
- W2000573492 hasConcept C121608353 @default.
- W2000573492 hasConcept C126322002 @default.
- W2000573492 hasConcept C143998085 @default.
- W2000573492 hasConcept C151730666 @default.
- W2000573492 hasConcept C177713679 @default.
- W2000573492 hasConcept C2778117688 @default.
- W2000573492 hasConcept C2779343474 @default.
- W2000573492 hasConcept C2780210213 @default.
- W2000573492 hasConcept C526805850 @default.
- W2000573492 hasConcept C71924100 @default.
- W2000573492 hasConcept C86803240 @default.
- W2000573492 hasConceptScore W2000573492C121608353 @default.
- W2000573492 hasConceptScore W2000573492C126322002 @default.
- W2000573492 hasConceptScore W2000573492C143998085 @default.
- W2000573492 hasConceptScore W2000573492C151730666 @default.
- W2000573492 hasConceptScore W2000573492C177713679 @default.
- W2000573492 hasConceptScore W2000573492C2778117688 @default.
- W2000573492 hasConceptScore W2000573492C2779343474 @default.
- W2000573492 hasConceptScore W2000573492C2780210213 @default.
- W2000573492 hasConceptScore W2000573492C526805850 @default.
- W2000573492 hasConceptScore W2000573492C71924100 @default.
- W2000573492 hasConceptScore W2000573492C86803240 @default.
- W2000573492 hasIssue "09" @default.
- W2000573492 hasLocation W20005734921 @default.