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- W2000573612 abstract "Programmed -1 ribosomal frameshifting (-1 PRF) is one viral translation strategy to express overlapping genes in positive-strand RNA viruses. Red clover necrotic mosaic virus (RCNMV) uses this strategy to express its replicase component protein p88. In this study, we used a cell-free translation system to map cis-acting RNA elements required for -1 PRF. Our results show that a small stem-loop structure adjacent to the cap-independent translation element in the 3' untranslated region (UTR) of RCNMV RNA1 is required for -1 PRF. Site-directed mutagenesis experiments suggested that this stem-loop regulates -1 PRF via base-pairing with complementary sequences in a bulged stem-loop adjacent to the shifty site. The existence of RNA elements responsible for -1 PRF and the cap-independent translation of replicase proteins in the 3' UTR of RNA1 might be important for switching translation to replication and for regulating the ratio of p88 to p27." @default.
- W2000573612 created "2016-06-24" @default.
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- W2000573612 date "2011-08-01" @default.
- W2000573612 modified "2023-10-01" @default.
- W2000573612 title "A long-distance RNA–RNA interaction plays an important role in programmed − 1 ribosomal frameshifting in the translation of p88 replicase protein of Red clover necrotic mosaic virus" @default.
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- W2000573612 doi "https://doi.org/10.1016/j.virol.2011.05.012" @default.
- W2000573612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7111920" @default.
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