Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000573793> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2000573793 endingPage "9" @default.
- W2000573793 startingPage "1" @default.
- W2000573793 abstract "The effects of age, gender, strain, phenobarbital (PB) treatment and pituitary influence on the regioselective metabolism of 7, 12-dimethylbenz[a]anthracene to hydroxmethyl metabolites were investigated. Studies used hepatic microsomal membranes from immature and mature Long Evans (LE) rats and adult Hooded Lister (HL) animals. Hydroxymethyl metabolites were resolved by both normal and reverse phase HPLC with on-line diode array detection. The CYP isoform(s) responsible for oxidation at the 12 methyl position exhibited no gender or developmental regulation and the rate of formation was not altered following hypophysectomy. PB-treatment of adult rats caused a significant increase in the rate of formation of both male and female animals (29 and 41-fold, respectively) suggesting a major contribution from a PB-inducible isoform, such as CYP2B. The rate of formation of 7OHMe12MBA exhibited no gender dependency in immature animals but was 2-fold greater than that observed for 12OHMe7MBA suggesting that steric hindrance resulting from the adjacent 1,2 benzyl ring favours substrate oxidation at the 7-methyl position. Male predominant formation of 7OHMe12MBA was apparent following sexual maturation of the LE rats and was significantly reduced upon hypophysectomy suggesting the involvement of a male-specific GH dependent isoform e.g. CYP2C11." @default.
- W2000573793 created "2016-06-24" @default.
- W2000573793 creator A5075762067 @default.
- W2000573793 creator A5079387157 @default.
- W2000573793 date "2000-09-01" @default.
- W2000573793 modified "2023-09-26" @default.
- W2000573793 title "The effect of gender, sexual maturation and xenobiotic treatment on the formation of hydroxymethyl metabolites from 7,12-dimethylbenz[a]anthracene in rat liver microsomes" @default.
- W2000573793 cites W1499429603 @default.
- W2000573793 cites W1500814526 @default.
- W2000573793 cites W1549399628 @default.
- W2000573793 cites W1590889826 @default.
- W2000573793 cites W1939276657 @default.
- W2000573793 cites W1943002371 @default.
- W2000573793 cites W1966050085 @default.
- W2000573793 cites W1970607529 @default.
- W2000573793 cites W1970724717 @default.
- W2000573793 cites W1981435376 @default.
- W2000573793 cites W1988017648 @default.
- W2000573793 cites W1992057754 @default.
- W2000573793 cites W1992574821 @default.
- W2000573793 cites W1997495700 @default.
- W2000573793 cites W2013920707 @default.
- W2000573793 cites W2016558716 @default.
- W2000573793 cites W2029877310 @default.
- W2000573793 cites W2034301223 @default.
- W2000573793 cites W2036800254 @default.
- W2000573793 cites W2048255261 @default.
- W2000573793 cites W2066546191 @default.
- W2000573793 cites W2073812348 @default.
- W2000573793 cites W2085726511 @default.
- W2000573793 cites W2092487388 @default.
- W2000573793 cites W2096491611 @default.
- W2000573793 cites W2132399066 @default.
- W2000573793 cites W2147405963 @default.
- W2000573793 cites W2416472161 @default.
- W2000573793 cites W4255527672 @default.
- W2000573793 doi "https://doi.org/10.1016/s0378-4274(00)00230-7" @default.
- W2000573793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11033228" @default.
- W2000573793 hasPublicationYear "2000" @default.
- W2000573793 type Work @default.
- W2000573793 sameAs 2000573793 @default.
- W2000573793 citedByCount "3" @default.
- W2000573793 countsByYear W20005737932021 @default.
- W2000573793 countsByYear W20005737932022 @default.
- W2000573793 crossrefType "journal-article" @default.
- W2000573793 hasAuthorship W2000573793A5075762067 @default.
- W2000573793 hasAuthorship W2000573793A5079387157 @default.
- W2000573793 hasConcept C126322002 @default.
- W2000573793 hasConcept C134018914 @default.
- W2000573793 hasConcept C181199279 @default.
- W2000573793 hasConcept C185592680 @default.
- W2000573793 hasConcept C2780104272 @default.
- W2000573793 hasConcept C55493867 @default.
- W2000573793 hasConcept C71315377 @default.
- W2000573793 hasConcept C71924100 @default.
- W2000573793 hasConcept C86803240 @default.
- W2000573793 hasConcept C87644729 @default.
- W2000573793 hasConceptScore W2000573793C126322002 @default.
- W2000573793 hasConceptScore W2000573793C134018914 @default.
- W2000573793 hasConceptScore W2000573793C181199279 @default.
- W2000573793 hasConceptScore W2000573793C185592680 @default.
- W2000573793 hasConceptScore W2000573793C2780104272 @default.
- W2000573793 hasConceptScore W2000573793C55493867 @default.
- W2000573793 hasConceptScore W2000573793C71315377 @default.
- W2000573793 hasConceptScore W2000573793C71924100 @default.
- W2000573793 hasConceptScore W2000573793C86803240 @default.
- W2000573793 hasConceptScore W2000573793C87644729 @default.
- W2000573793 hasIssue "1-2" @default.
- W2000573793 hasLocation W20005737931 @default.
- W2000573793 hasLocation W20005737932 @default.
- W2000573793 hasOpenAccess W2000573793 @default.
- W2000573793 hasPrimaryLocation W20005737931 @default.
- W2000573793 hasRelatedWork W2010558189 @default.
- W2000573793 hasRelatedWork W2013157546 @default.
- W2000573793 hasRelatedWork W2058509918 @default.
- W2000573793 hasRelatedWork W2060160349 @default.
- W2000573793 hasRelatedWork W2064140499 @default.
- W2000573793 hasRelatedWork W2081077785 @default.
- W2000573793 hasRelatedWork W2094230228 @default.
- W2000573793 hasRelatedWork W2127054680 @default.
- W2000573793 hasRelatedWork W2139297898 @default.
- W2000573793 hasRelatedWork W2109473735 @default.
- W2000573793 hasVolume "117" @default.
- W2000573793 isParatext "false" @default.
- W2000573793 isRetracted "false" @default.
- W2000573793 magId "2000573793" @default.
- W2000573793 workType "article" @default.