Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000575196> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2000575196 abstract "1. The protective effects of ten slow channel inhibitor drugs against severe progressive hypoxia were investigated in rats breathing spontaneously during light anaesthesia. Respiration, heart rate, electrocorticogram (ECoG) and/or electroencephalogram (EEG) were recorded. 2. Tolerance times were monitored from hypoxia onset until cessation of respiration, ECoG, EEG synchronization, and 'background-EEG'. Drugs were administered i.v. 5 min before the onset of hypoxia. 3. Verapamil, gallopamil, and nimodipine resulted in a significant increase of tolerance times; fendiline and bepridil showed a small increase (not significant); bencyclan and prenylamine were ineffective; cinnarizine and diltiazem slightly reduced tolerance times as did flunarizine at low doses. 4. At protective doses, verapamil, gallopamil, and nimodipine significantly raised the respiration rate but had little or no cardiac depressor effects. Bencyclan showed ventilatory drive but cardiocirculatory depression. A clear-cut ventilatory drive did not occur with the other ineffective slow channel inhibitors. 5. It is suggested that the protective actions observed were not due to slow channel inhibition per se, nor to spasmolytic potency or increased cerebral blood flow. Ventilatory drive associated with other cardiopulmonary actions which secondarily raise the brain oxygen supply are likely to be responsible for this effect." @default.
- W2000575196 created "2016-06-24" @default.
- W2000575196 creator A5045780837 @default.
- W2000575196 date "1988-11-01" @default.
- W2000575196 modified "2023-09-27" @default.
- W2000575196 title "Slow channel inhibitor effects on brain function: tolerance to severe hypoxia in the rat" @default.
- W2000575196 cites W1985601113 @default.
- W2000575196 cites W1991457212 @default.
- W2000575196 cites W1995272882 @default.
- W2000575196 cites W2008767496 @default.
- W2000575196 cites W2009690028 @default.
- W2000575196 cites W2015488066 @default.
- W2000575196 cites W2019663398 @default.
- W2000575196 cites W2030040645 @default.
- W2000575196 cites W2037159899 @default.
- W2000575196 cites W2047185197 @default.
- W2000575196 cites W2047340324 @default.
- W2000575196 cites W2048172495 @default.
- W2000575196 cites W2053762563 @default.
- W2000575196 cites W2056987304 @default.
- W2000575196 cites W2073296432 @default.
- W2000575196 cites W2080971418 @default.
- W2000575196 cites W2086714946 @default.
- W2000575196 cites W2117796487 @default.
- W2000575196 cites W2140391836 @default.
- W2000575196 cites W2277730992 @default.
- W2000575196 cites W2397612534 @default.
- W2000575196 cites W2409227737 @default.
- W2000575196 cites W2410076190 @default.
- W2000575196 cites W2412731213 @default.
- W2000575196 cites W2413710421 @default.
- W2000575196 cites W2415547773 @default.
- W2000575196 cites W2417562176 @default.
- W2000575196 cites W2418036287 @default.
- W2000575196 cites W2419599346 @default.
- W2000575196 cites W65007250 @default.
- W2000575196 doi "https://doi.org/10.1111/j.1476-5381.1988.tb11720.x" @default.
- W2000575196 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1854241" @default.
- W2000575196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3264735" @default.
- W2000575196 hasPublicationYear "1988" @default.
- W2000575196 type Work @default.
- W2000575196 sameAs 2000575196 @default.
- W2000575196 citedByCount "7" @default.
- W2000575196 crossrefType "journal-article" @default.
- W2000575196 hasAuthorship W2000575196A5045780837 @default.
- W2000575196 hasBestOaLocation W20005751962 @default.
- W2000575196 hasConcept C126322002 @default.
- W2000575196 hasConcept C178790620 @default.
- W2000575196 hasConcept C185592680 @default.
- W2000575196 hasConcept C2776741139 @default.
- W2000575196 hasConcept C2777022698 @default.
- W2000575196 hasConcept C2777286116 @default.
- W2000575196 hasConcept C2777294900 @default.
- W2000575196 hasConcept C2777953023 @default.
- W2000575196 hasConcept C2779066535 @default.
- W2000575196 hasConcept C2779995051 @default.
- W2000575196 hasConcept C42219234 @default.
- W2000575196 hasConcept C519063684 @default.
- W2000575196 hasConcept C540031477 @default.
- W2000575196 hasConcept C71924100 @default.
- W2000575196 hasConcept C7836513 @default.
- W2000575196 hasConcept C84393581 @default.
- W2000575196 hasConcept C98274493 @default.
- W2000575196 hasConceptScore W2000575196C126322002 @default.
- W2000575196 hasConceptScore W2000575196C178790620 @default.
- W2000575196 hasConceptScore W2000575196C185592680 @default.
- W2000575196 hasConceptScore W2000575196C2776741139 @default.
- W2000575196 hasConceptScore W2000575196C2777022698 @default.
- W2000575196 hasConceptScore W2000575196C2777286116 @default.
- W2000575196 hasConceptScore W2000575196C2777294900 @default.
- W2000575196 hasConceptScore W2000575196C2777953023 @default.
- W2000575196 hasConceptScore W2000575196C2779066535 @default.
- W2000575196 hasConceptScore W2000575196C2779995051 @default.
- W2000575196 hasConceptScore W2000575196C42219234 @default.
- W2000575196 hasConceptScore W2000575196C519063684 @default.
- W2000575196 hasConceptScore W2000575196C540031477 @default.
- W2000575196 hasConceptScore W2000575196C71924100 @default.
- W2000575196 hasConceptScore W2000575196C7836513 @default.
- W2000575196 hasConceptScore W2000575196C84393581 @default.
- W2000575196 hasConceptScore W2000575196C98274493 @default.
- W2000575196 hasLocation W20005751961 @default.
- W2000575196 hasLocation W20005751962 @default.
- W2000575196 hasLocation W20005751963 @default.
- W2000575196 hasLocation W20005751964 @default.
- W2000575196 hasOpenAccess W2000575196 @default.
- W2000575196 hasPrimaryLocation W20005751961 @default.
- W2000575196 hasRelatedWork W1966139957 @default.
- W2000575196 hasRelatedWork W1988074297 @default.
- W2000575196 hasRelatedWork W2000575196 @default.
- W2000575196 hasRelatedWork W2053218361 @default.
- W2000575196 hasRelatedWork W2069277129 @default.
- W2000575196 hasRelatedWork W2079618320 @default.
- W2000575196 hasRelatedWork W2148282970 @default.
- W2000575196 hasRelatedWork W289165833 @default.
- W2000575196 hasRelatedWork W1893183326 @default.
- W2000575196 hasRelatedWork W2001641233 @default.
- W2000575196 isParatext "false" @default.
- W2000575196 isRetracted "false" @default.
- W2000575196 magId "2000575196" @default.
- W2000575196 workType "article" @default.