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- W2000577005 abstract "Primary cultures of juvenile eel (Anguilla anguilla) pituitary cells were used to study the direct effects of sex steroids on gonadotropin (GtH-II) cell content and release (radioimmunoassay) as well as on mRNAs levels for α and GtH-II β-subunits (dot-blot). Testosterone stimulated GtH-II production in a dose- and time-dependent manner by selectively increasing mRNAs for GtH-II β-subunit but not α-subunit. This positive effect was also induced by non-aromatizable androgens (androstanediol and dihydrotestosterone) but not by estradiol, indicating an androgen-specific effect in the eel. The androgen-specific stimulation of eel GtH-II β appears closer to the regulation of mammalian follice stimulating hormone-β (FSHβ) than that of salmonid GtH-II β or mammalian luteinizing hormone-β (LHβ)-subunits. Comparison with previous in vivo experiments suggests multiple sites of action of sex steroids on the brain-pituitary gonadotropic axis for the positive feedback on GtH-II synthesis in this juvenile fish." @default.
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- W2000577005 date "1997-08-01" @default.
- W2000577005 modified "2023-10-14" @default.
- W2000577005 title "Androgens stimulate gonadotropin-II β-subunit in eel pituitary cells in vitro" @default.
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- W2000577005 doi "https://doi.org/10.1016/s0303-7207(97)00100-7" @default.
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