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• W2000578376 abstract "The size and shape of organs depend on cellular processes such as cell proliferation, cell survival, and spatial arrangement of cells. In turn, all of these processes are a consequence of positional identity of individual cells in whole organs. Links of positional information with organ growth and pattern expression of genes is a little-addressed question. We show that differences in vestigial expression between neighboring cells of the wing blade autonomously and nonautonomously affect cell proliferation along the proximo-distal axis. On the other hand, uniform expression of vestigial inhibits cell proliferation and also perturbs the shape of wing blade altering the preferential orientation of cell divisions. Our observations provide evidence that local cell interactions, triggered by differences in vestigial expression between neighboring cells, confer positional values operating in the control of growth and shape of the wing." @default.
• W2000578376 created "2016-06-24" @default.
• W2000578376 creator A5016154022 @default.
• W2000578376 creator A5061953464 @default.
• W2000578376 date "2006-09-12" @default.
• W2000578376 modified "2023-09-25" @default.
• W2000578376 title "Control of growth and positional information by the graded <i>vestigial</i> expression pattern in the wing of <i>Drosophila</i> <i>melanogaster</i>" @default.
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• W2000578376 doi "https://doi.org/10.1073/pnas.0606092103" @default.
• W2000578376 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1564234" @default.
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