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- W2000578518 abstract "Cycloheximide produced a 10-fold increase in the incorporation of glucose into lipids of the rat epididymal fat pad and a 43 per cent decrease in plasma free fatty acids. These changes were observed 2hr after the intraperitoneal injection of 1 mg/kg of the antibiotic to male rats fasted for 16–20hr and weighing between 120 and 170 g. Under the same conditions, subcutaneous adipose tissue showed a 2-fold increase, while brain, liver and brown adipose tissue did not give any response. The 10-fold increase was absent in fed rats and was lower (4-fold) in male animals weighing over 250 g and in 120–170 g female rats when the parametrial adipose tissue was studied. The higher incorporation of glucose into lipids produced by Cycloheximide was also smaller in the epididymal fat pad from orchiectomized (2-fold), adrenalectomized (3-fold) and alloxan diabetic (7-fold) rats. Hormonal substitutive treatment with testosterone in orchiectomized animals and with cortisol, corticosterone or epinephrine in adrenalectomized animals did not elicit the response obtained in intact rats. The relative distribution of the label from radioactive glucose into lipid extracts between glycerol and fatty acids after Cycloheximide treatment resembles that found in control rats, but differs from that observed after insulin administration. Actinomycin-D, chloramphenicol and puromycin did not mimic the action of cycloheximide on lipid metabolism. Epididymal fat pads obtained from fasted male rats injected 1 hr earlier with Cycloheximide showed, after 60 min of incubation, a 5-fold increase in the incorporation of glucose into lipids, a 37 per cent increase in the release of glycerol and a 36 per cent diminution in the release of free fatty acids into the incubation mixture, when compared to the values obtained with the tissues of the control animals. It is postulated that in the rat epididymal fat pad Cycloheximide has a marked lipogenic effect together with an accelerated fatty acid re-esterification which is independent of both insulin secretion and inhibition of protein synthesis." @default.
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- W2000578518 date "1965-01-01" @default.
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- W2000578518 title "RNA synthesis of yeast in the presence of cycloheximide" @default.
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- W2000578518 doi "https://doi.org/10.1016/0006-291x(65)90757-6" @default.
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