FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000578798> ?p ?o ?g. }

• W2000578798 endingPage "387" @default.
• W2000578798 startingPage "382" @default.
• W2000578798 abstract "The amphetamine analog 3,4-methylenedioxymethamphetamine (MDMA) is considered to be selectively neurotoxic to serotonergic nerve terminals. Although the long term effects of MDMA on serotonin (5-HT) terminals have been well studied, other potential neurochemical consequences associated with MDMA-induced 5-HT depletion have been less well investigated. In view of the cognitive impairments in human MDMA abusers and the role of acetylcholine (ACh) in learning and memory, it was of interest to determine the influence of a 5-HT depleting regimen of MDMA on subsequent stimulation of ACh release in the prefrontal cortex (PFC). Male rats received vehicle or MDMA (10 mg/kg, i.p. every 2 h for four injections) and underwent in vivo microdialysis 7 days later to assess the subsequent drug- (e.g., MDMA, 5-HT1A agonist) or stress- (e.g., tail pinch, presence of an intruder rat) induced stimulation of ACh release. The increase in the extracellular concentration of ACh in the PFC produced by MDMA (10 mg/kg, i.p.) was significantly less in rats previously exposed to the neurotoxic regimen of MDMA than that in control animals. In contrast, there was no difference in the magnitude of the stimulation of cortical ACh release elicited by the 5-HT1A agonist, 8-hydroxy-2-(di-n-propyl-amino)tetralin (8-OH-DPAT, 0.3mg/kg, s.c.), tail pinch (30 min) or the presence of an intruder rat (40 min) between control animals and animals previously exposed to a neurotoxic regimen of MDMA. These results suggest that although MDMA-induced 5-HT depletion diminishes subsequent MDMA-induced ACh release, there is little impact on cortical ACh release elicited by the stress of pain or the novelty of an environmental intruder." @default.
• W2000578798 created "2016-06-24" @default.
• W2000578798 creator A5029513865 @default.
• W2000578798 creator A5083943770 @default.
• W2000578798 date "2006-04-01" @default.
• W2000578798 modified "2023-09-27" @default.
• W2000578798 title "Effect of a serotonin depleting regimen of 3,4-methylenedioxymethamphetamine (MDMA) on the subsequent stimulation of acetylcholine release in the rat prefrontal cortex" @default.
• W2000578798 cites W1597954511 @default.
• W2000578798 cites W1600050350 @default.
• W2000578798 cites W1899272159 @default.
• W2000578798 cites W1978787522 @default.
• W2000578798 cites W1983786855 @default.
• W2000578798 cites W1983885383 @default.
• W2000578798 cites W1987507203 @default.
• W2000578798 cites W1990692265 @default.
• W2000578798 cites W1991339455 @default.
• W2000578798 cites W1994647182 @default.
• W2000578798 cites W2014948578 @default.
• W2000578798 cites W2021041549 @default.
• W2000578798 cites W2029675439 @default.
• W2000578798 cites W2049804872 @default.
• W2000578798 cites W2050415436 @default.
• W2000578798 cites W2061414707 @default.
• W2000578798 cites W2061733755 @default.
• W2000578798 cites W2066213523 @default.
• W2000578798 cites W2067948112 @default.
• W2000578798 cites W2068360712 @default.
• W2000578798 cites W2073494415 @default.
• W2000578798 cites W2078056234 @default.
• W2000578798 cites W2083687710 @default.
• W2000578798 cites W2094508033 @default.
• W2000578798 cites W2095188030 @default.
• W2000578798 cites W2117468337 @default.
• W2000578798 cites W2122034964 @default.
• W2000578798 cites W2134647442 @default.
• W2000578798 cites W2143437320 @default.
• W2000578798 cites W2146353697 @default.
• W2000578798 cites W2146745496 @default.
• W2000578798 cites W2153762687 @default.
• W2000578798 cites W2155890773 @default.
• W2000578798 cites W2168659851 @default.
• W2000578798 cites W2059553248 @default.
• W2000578798 doi "https://doi.org/10.1016/j.brainresbull.2006.01.011" @default.
• W2000578798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16624669" @default.
• W2000578798 hasPublicationYear "2006" @default.
• W2000578798 type Work @default.
• W2000578798 sameAs 2000578798 @default.
• W2000578798 citedByCount "17" @default.
• W2000578798 countsByYear W20005787982012 @default.
• W2000578798 countsByYear W20005787982014 @default.
• W2000578798 countsByYear W20005787982015 @default.
• W2000578798 countsByYear W20005787982016 @default.
• W2000578798 countsByYear W20005787982018 @default.
• W2000578798 countsByYear W20005787982021 @default.
• W2000578798 crossrefType "journal-article" @default.
• W2000578798 hasAuthorship W2000578798A5029513865 @default.
• W2000578798 hasAuthorship W2000578798A5083943770 @default.
• W2000578798 hasConcept C126322002 @default.
• W2000578798 hasConcept C134018914 @default.
• W2000578798 hasConcept C15744967 @default.
• W2000578798 hasConcept C170493617 @default.
• W2000578798 hasConcept C185592680 @default.
• W2000578798 hasConcept C24998067 @default.
• W2000578798 hasConcept C25876315 @default.
• W2000578798 hasConcept C2775864247 @default.
• W2000578798 hasConcept C2775910092 @default.
• W2000578798 hasConcept C2776219046 @default.
• W2000578798 hasConcept C2777193897 @default.
• W2000578798 hasConcept C2778938600 @default.
• W2000578798 hasConcept C2780062018 @default.
• W2000578798 hasConcept C2780876324 @default.
• W2000578798 hasConcept C37000724 @default.
• W2000578798 hasConcept C50156730 @default.
• W2000578798 hasConcept C513476851 @default.
• W2000578798 hasConcept C529278444 @default.
• W2000578798 hasConcept C71924100 @default.
• W2000578798 hasConcept C98274493 @default.
• W2000578798 hasConceptScore W2000578798C126322002 @default.
• W2000578798 hasConceptScore W2000578798C134018914 @default.
• W2000578798 hasConceptScore W2000578798C15744967 @default.
• W2000578798 hasConceptScore W2000578798C170493617 @default.
• W2000578798 hasConceptScore W2000578798C185592680 @default.
• W2000578798 hasConceptScore W2000578798C24998067 @default.
• W2000578798 hasConceptScore W2000578798C25876315 @default.
• W2000578798 hasConceptScore W2000578798C2775864247 @default.
• W2000578798 hasConceptScore W2000578798C2775910092 @default.
• W2000578798 hasConceptScore W2000578798C2776219046 @default.
• W2000578798 hasConceptScore W2000578798C2777193897 @default.
• W2000578798 hasConceptScore W2000578798C2778938600 @default.
• W2000578798 hasConceptScore W2000578798C2780062018 @default.
• W2000578798 hasConceptScore W2000578798C2780876324 @default.
• W2000578798 hasConceptScore W2000578798C37000724 @default.
• W2000578798 hasConceptScore W2000578798C50156730 @default.
• W2000578798 hasConceptScore W2000578798C513476851 @default.
• W2000578798 hasConceptScore W2000578798C529278444 @default.
• W2000578798 hasConceptScore W2000578798C71924100 @default.
• W2000578798 hasConceptScore W2000578798C98274493 @default.
• W2000578798 hasIssue "4" @default.

• next