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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000579631> ?p ?o ?g. }

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• W2000579631 abstract "<h2>Abstract</h2> Defects in signal transduction mechanisms may underlie the impaired aggregation and secretion in patients with congenital platelet function defects (CPD). Both protein kinase C (PKC) induced pleckstrin phosphorylation and cytoplasmic Ca²⁺ mobilization play a major role in secretion. We postulated that combined platelet activation with a cell permeable direct PKC activator 1,2-dioctanoyl-sn-glycerol (DiC₈) and ionophore A23187, which possibly bypass the steps involved in the intracellular synthesis of two major mediators (inositol trisphosphate, diacylglycerol), may induce normal dense granule secretion in patients with impaired receptor mediated secretion. We studied eight CPD patients with abnormal aggregation and secretion in response to several different surface receptor-mediated agonists despite the presence of normal dense granule contents. Receptor mediated Ca²⁺ mobilization and/or pleckstrin phosphorylation were abnormal in seven patients. Platelet activation with a combination of ADP (8 μM) with DiC₈ (200 μM) or A23187 (10 μM) improved secretion in four patients. However, platelet activation with a combination of 200 μM DiC₈ with 10 μM A23187, or 100 μM DiC₈ with 5 μM A23187 induced normal secretion in platelet-rich plasma in all patients. These studies suggest that in such patients with CPD the ultimate process of exocytosis or secretion per se is intact and impaired secretion results from abnormalities in early signal transduction events, possibly upstream of diacylglycerol formation and calcium mobilization. Detailed studies are needed to delineate the specific abnormalities in these heterogenous patients with signal transduction defects." @default.
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• W2000579631 date "1997-11-01" @default.
• W2000579631 modified "2023-09-25" @default.
• W2000579631 title "Platelet Activation with Combination of Ionophore A23187 and a Direct Protein Kinase C Activator Induces Normal Secretion in Patients with Impaired Receptor Mediated Secretion and Abnormal Signal Transduction" @default.
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• W2000579631 doi "https://doi.org/10.1016/s0049-3848(97)00261-2" @default.
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