Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000579954> ?p ?o ?g. }
- W2000579954 endingPage "650" @default.
- W2000579954 startingPage "636" @default.
- W2000579954 abstract "Diabetic nephropathy (DN) is a frequent complication in patients with diabetes mellitus. To find improved intervention strategies in this disease, it is necessary to investigate the molecular mechanisms involved. To obtain more insight into processes that lead to DN, messenger RNA expression profiles of diabetic glomeruli and glomeruli from healthy individuals were compared.Two morphologically normal kidneys and 2 kidneys from patients with DN were used for the study. Glomerular RNA was hybridized in duplicate on Human Genome U95Av2 Arrays (Affymetrix, Santa Clara, CA). Several transcripts were tested further in independent patient groups and at the protein level by immunohistochemistry.Ninety-six genes were upregulated in diabetic glomeruli, whereas 519 genes were downregulated. The list of overexpressed genes in DN includes aquaporin 1, calpain 3, hyaluronoglucosidase, and platelet/endothelial cell adhesion molecule. The list of downregulated genes includes bone morphogenetic protein 2, vascular endothelial growth factor (VEGF), fibroblast growth factor 1, insulin-like growth factor binding protein 2, and nephrin. A decrease in VEGF and nephrin could be validated at the protein level and also at the RNA level in renal biopsy specimens from 5 additional patients with diabetes.Results of oligonucleotide microarray analyses on control and diabetic glomeruli are presented and discussed in their relation to vascular damage, mesangial matrix expansion, proliferation, and proteinuria. Our findings suggest that progression of DN might result from diminished tissue repair capability." @default.
- W2000579954 created "2016-06-24" @default.
- W2000579954 creator A5000085661 @default.
- W2000579954 creator A5003754642 @default.
- W2000579954 creator A5004743827 @default.
- W2000579954 creator A5021917052 @default.
- W2000579954 creator A5063207633 @default.
- W2000579954 creator A5070689180 @default.
- W2000579954 date "2004-04-01" @default.
- W2000579954 modified "2023-10-18" @default.
- W2000579954 title "Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy" @default.
- W2000579954 cites W1481302063 @default.
- W2000579954 cites W1963648288 @default.
- W2000579954 cites W1982125065 @default.
- W2000579954 cites W1985432260 @default.
- W2000579954 cites W1986454739 @default.
- W2000579954 cites W1989856647 @default.
- W2000579954 cites W1994360646 @default.
- W2000579954 cites W1998078558 @default.
- W2000579954 cites W2006871752 @default.
- W2000579954 cites W2006996389 @default.
- W2000579954 cites W2009729476 @default.
- W2000579954 cites W2019676554 @default.
- W2000579954 cites W2020479094 @default.
- W2000579954 cites W2023407328 @default.
- W2000579954 cites W2028940749 @default.
- W2000579954 cites W2031085640 @default.
- W2000579954 cites W2032784439 @default.
- W2000579954 cites W2042050184 @default.
- W2000579954 cites W2049276892 @default.
- W2000579954 cites W2050332600 @default.
- W2000579954 cites W2061202476 @default.
- W2000579954 cites W2063152865 @default.
- W2000579954 cites W2071958606 @default.
- W2000579954 cites W2077313482 @default.
- W2000579954 cites W2091321868 @default.
- W2000579954 cites W2092711749 @default.
- W2000579954 cites W2096120926 @default.
- W2000579954 cites W2101417448 @default.
- W2000579954 cites W2101651570 @default.
- W2000579954 cites W2112549609 @default.
- W2000579954 cites W2125740630 @default.
- W2000579954 cites W2128230258 @default.
- W2000579954 cites W2129416468 @default.
- W2000579954 cites W2131989143 @default.
- W2000579954 cites W2138081719 @default.
- W2000579954 cites W2170471212 @default.
- W2000579954 cites W2268596767 @default.
- W2000579954 doi "https://doi.org/10.1053/j.ajkd.2003.12.028" @default.
- W2000579954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15042541" @default.
- W2000579954 hasPublicationYear "2004" @default.
- W2000579954 type Work @default.
- W2000579954 sameAs 2000579954 @default.
- W2000579954 citedByCount "176" @default.
- W2000579954 countsByYear W20005799542012 @default.
- W2000579954 countsByYear W20005799542013 @default.
- W2000579954 countsByYear W20005799542014 @default.
- W2000579954 countsByYear W20005799542015 @default.
- W2000579954 countsByYear W20005799542016 @default.
- W2000579954 countsByYear W20005799542017 @default.
- W2000579954 countsByYear W20005799542018 @default.
- W2000579954 countsByYear W20005799542019 @default.
- W2000579954 countsByYear W20005799542020 @default.
- W2000579954 countsByYear W20005799542021 @default.
- W2000579954 countsByYear W20005799542022 @default.
- W2000579954 countsByYear W20005799542023 @default.
- W2000579954 crossrefType "journal-article" @default.
- W2000579954 hasAuthorship W2000579954A5000085661 @default.
- W2000579954 hasAuthorship W2000579954A5003754642 @default.
- W2000579954 hasAuthorship W2000579954A5004743827 @default.
- W2000579954 hasAuthorship W2000579954A5021917052 @default.
- W2000579954 hasAuthorship W2000579954A5063207633 @default.
- W2000579954 hasAuthorship W2000579954A5070689180 @default.
- W2000579954 hasConcept C104317684 @default.
- W2000579954 hasConcept C126322002 @default.
- W2000579954 hasConcept C127561419 @default.
- W2000579954 hasConcept C134018914 @default.
- W2000579954 hasConcept C167734588 @default.
- W2000579954 hasConcept C2777025900 @default.
- W2000579954 hasConcept C2777146197 @default.
- W2000579954 hasConcept C2777390665 @default.
- W2000579954 hasConcept C2779561371 @default.
- W2000579954 hasConcept C2779922275 @default.
- W2000579954 hasConcept C2780091579 @default.
- W2000579954 hasConcept C2780819817 @default.
- W2000579954 hasConcept C54355233 @default.
- W2000579954 hasConcept C555293320 @default.
- W2000579954 hasConcept C71924100 @default.
- W2000579954 hasConcept C86803240 @default.
- W2000579954 hasConceptScore W2000579954C104317684 @default.
- W2000579954 hasConceptScore W2000579954C126322002 @default.
- W2000579954 hasConceptScore W2000579954C127561419 @default.
- W2000579954 hasConceptScore W2000579954C134018914 @default.
- W2000579954 hasConceptScore W2000579954C167734588 @default.
- W2000579954 hasConceptScore W2000579954C2777025900 @default.
- W2000579954 hasConceptScore W2000579954C2777146197 @default.
- W2000579954 hasConceptScore W2000579954C2777390665 @default.
- W2000579954 hasConceptScore W2000579954C2779561371 @default.