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- W2000580034 abstract "Coating of the X chromosome by Xist RNA is an essential trigger for X inactivation. However, little is known about the early chromatin remodeling events that transform this signal into transcriptional silencing. Here we report that methylation of histone H3 lysine 9 on the inactive X chromosome occurs immediately after Xist RNA coating and before transcriptional inactivation of X-linked genes. X-chromosomal H3 Lys-9 methylation occurs during the same window of time as H3 Lys-9 hypoacetylation and H3 Lys-4 hypomethylation. Histone H3 modifications thus represent the earliest known chromatin changes during X inactivation. We also identify a unique hotspot of H3 Lys-9 methylation 5' to Xist, and we propose that this acts as a nucleation center for Xist RNA-dependent spread of inactivation along the X chromosome via H3 Lys-9 methylation." @default.
- W2000580034 created "2016-06-24" @default.
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- W2000580034 date "2001-12-01" @default.
- W2000580034 modified "2023-10-16" @default.
- W2000580034 title "Methylation of Histone H3 at Lys-9 Is an Early Mark on the X Chromosome during X Inactivation" @default.
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- W2000580034 doi "https://doi.org/10.1016/s0092-8674(01)00598-0" @default.
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