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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000581973> ?p ?o ?g. }

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• W2000581973 abstract "Portal fibroblasts (PF) are a newly isolated population of fibrogenic cells in the liver postulated to play a significant role in early biliary fibrosis. Because transforming growth factor‐β (TGF)‐β is a key growth factor in fibrosis, we characterized the response of PF to TGF‐β. We demonstrate that PF produce significant amounts of TGF‐β2 and, unlike activated hepatic stellate cells (HSC), express all three TGF‐β receptors and are growth inhibited by TGF‐β1 and TGF‐β2. Fibroblast growth factor (FGF)‐2, but not platelet derived growth factor (PDGF), causes PF proliferation. These data suggest a mechanism whereby HSC eclipse PF as the dominant myofibroblast population in biliary fibrosis." @default.
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• W2000581973 date "2004-01-22" @default.
• W2000581973 modified "2023-10-16" @default.
• W2000581973 title "Autocrine release of TGF-β by portal fibroblasts regulates cell growth" @default.
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• W2000581973 doi "https://doi.org/10.1016/s0014-5793(04)00037-7" @default.
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