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- W2000582841 abstract "In a double blind randomised multicentre study the effect of intravenous clodronate plus hydration was compared with placebo plus hydration in the treatment of hypercalcaemia in breast cancer patients with bone metastases. The patients were treated either with hydration plus clodronate 300 mg/day or hydration plus placebo, up to 7 days or until serum ionised calcium was below 1.4 mmol/l. 25 patients received clodronate and 19 placebo. A significant difference in favour of clodronate was observed in the time to reach normocalcaemia (P = 0.004) and in the number of patients achieving normocalcaemia (P = 0.0003). 17 patients of 21 evaluable patients on clodronate achieved normocalcaemia compared with 4 of 19 patients on placebo. The only adverse event clearly associated with clodronate was symptomatic hypocalcaemia in 1 patient. Thus, clodronate seems to be a safe and highly efficacious drug for the treatment of hypercalcaemia in breast cancer patients." @default.
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- W2000582841 date "1992-04-01" @default.
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- W2000582841 title "Intravenous clodronate for the treatment of hypercalcaemia in breast cancer patients with bone metastases—A prospective randomised placebo-controlled multicentre study" @default.
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- W2000582841 doi "https://doi.org/10.1016/0959-8049(92)90143-p" @default.
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