FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000583605> ?p ?o ?g. }

• W2000583605 endingPage "319" @default.
• W2000583605 startingPage "313" @default.
• W2000583605 abstract "Verapamil, a calcium antagonist, has been used extensively for treatment of cardiac arrhythmias. Concern persists, however, that it may seriously depress myocardial function in cardiac patients. To investigate this possibility, 20 patients with coronary artery disease (CAD) but no heart failure were given intravenous verapamil (0.1 mg/kg bolus, followed by 0.005 mg/kg/min infusion), and studied hemodynamically and angiographically. Verapamil markedly lowered mean aortic pressure (94 +/- 17 to 82 +/- 13 mm Hg, p less than 0.0005) and systemic vascular resistance (1413 +/- 429 to 1069 +/- 235 dyn-sec-cm5, p less than 0.0005). Simultaneously, all indices of left ventricular (LV) performance greatly improved: cardiac index rose from 2.8 +/- 0.6 to 3.1 +/- 0.7 1/min/m2 (p less than 0.0005), mean velocity of circumferential fiber shortening increased from 0.85 +/- 0.39 to 0.97 +/- 0.46 circ/sec (p less than 0.01), and ejection fraction improved from 55 +/- 16 to 61 +/- 18% (p less than 0.01). No significant changes were noted in the heart rate before and after verapamil administration, and verapamil did not worsen the extent of LV asynergy in the majority of patients. In patients with CAD, the intrinsic negative inotropic effect of verapamil is of negligible importance because its potent vasodilatory properties more than compensate for any intrinsic decrease in LV contractility, and thereby improve the overall cardiac function." @default.
• W2000583605 created "2016-06-24" @default.
• W2000583605 creator A5010941258 @default.
• W2000583605 creator A5057568897 @default.
• W2000583605 creator A5091070572 @default.
• W2000583605 date "1979-02-01" @default.
• W2000583605 modified "2023-09-27" @default.
• W2000583605 title "Effects of verapamil on myocardial performance in coronary disease." @default.
• W2000583605 cites W1545401863 @default.
• W2000583605 cites W171704982 @default.
• W2000583605 cites W1964486223 @default.
• W2000583605 cites W1965953785 @default.
• W2000583605 cites W1968289991 @default.
• W2000583605 cites W1971054363 @default.
• W2000583605 cites W1984837851 @default.
• W2000583605 cites W1985500599 @default.
• W2000583605 cites W1986168059 @default.
• W2000583605 cites W1990102962 @default.
• W2000583605 cites W1992201970 @default.
• W2000583605 cites W1993179456 @default.
• W2000583605 cites W1995437073 @default.
• W2000583605 cites W1997676851 @default.
• W2000583605 cites W1998949580 @default.
• W2000583605 cites W2002854148 @default.
• W2000583605 cites W2002935471 @default.
• W2000583605 cites W2017533404 @default.
• W2000583605 cites W2018269316 @default.
• W2000583605 cites W2023004275 @default.
• W2000583605 cites W2025618821 @default.
• W2000583605 cites W2026250248 @default.
• W2000583605 cites W2033021843 @default.
• W2000583605 cites W2034150239 @default.
• W2000583605 cites W2035064501 @default.
• W2000583605 cites W2035203891 @default.
• W2000583605 cites W2039196715 @default.
• W2000583605 cites W2045954035 @default.
• W2000583605 cites W2050082580 @default.
• W2000583605 cites W2050716802 @default.
• W2000583605 cites W2051987695 @default.
• W2000583605 cites W2055414887 @default.
• W2000583605 cites W2060776286 @default.
• W2000583605 cites W2065010839 @default.
• W2000583605 cites W2070509408 @default.
• W2000583605 cites W2070903243 @default.
• W2000583605 cites W2074586133 @default.
• W2000583605 cites W2074857558 @default.
• W2000583605 cites W2075238739 @default.
• W2000583605 cites W2075936164 @default.
• W2000583605 cites W2076586712 @default.
• W2000583605 cites W2078178947 @default.
• W2000583605 cites W2086509452 @default.
• W2000583605 cites W2087425441 @default.
• W2000583605 cites W2095127588 @default.
• W2000583605 cites W2109461622 @default.
• W2000583605 cites W2111322267 @default.
• W2000583605 cites W2117722214 @default.
• W2000583605 cites W2134134275 @default.
• W2000583605 cites W2145164028 @default.
• W2000583605 cites W2147101763 @default.
• W2000583605 cites W2156880631 @default.
• W2000583605 cites W2166787037 @default.
• W2000583605 cites W2336120846 @default.
• W2000583605 cites W2338897659 @default.
• W2000583605 cites W2418341223 @default.
• W2000583605 cites W48321022 @default.
• W2000583605 doi "https://doi.org/10.1161/01.cir.59.2.313" @default.
• W2000583605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/365390" @default.
• W2000583605 hasPublicationYear "1979" @default.
• W2000583605 type Work @default.
• W2000583605 sameAs 2000583605 @default.
• W2000583605 citedByCount "169" @default.
• W2000583605 countsByYear W20005836052019 @default.
• W2000583605 countsByYear W20005836052021 @default.
• W2000583605 crossrefType "journal-article" @default.
• W2000583605 hasAuthorship W2000583605A5010941258 @default.
• W2000583605 hasAuthorship W2000583605A5057568897 @default.
• W2000583605 hasAuthorship W2000583605A5091070572 @default.
• W2000583605 hasBestOaLocation W20005836051 @default.
• W2000583605 hasConcept C111566952 @default.
• W2000583605 hasConcept C120770815 @default.
• W2000583605 hasConcept C126322002 @default.
• W2000583605 hasConcept C139940330 @default.
• W2000583605 hasConcept C155710745 @default.
• W2000583605 hasConcept C164705383 @default.
• W2000583605 hasConcept C178853913 @default.
• W2000583605 hasConcept C2777022698 @default.
• W2000583605 hasConcept C2778198053 @default.
• W2000583605 hasConcept C2778213512 @default.
• W2000583605 hasConcept C2909076160 @default.
• W2000583605 hasConcept C31861589 @default.
• W2000583605 hasConcept C39133596 @default.
• W2000583605 hasConcept C519063684 @default.
• W2000583605 hasConcept C71924100 @default.
• W2000583605 hasConcept C78085059 @default.
• W2000583605 hasConceptScore W2000583605C111566952 @default.
• W2000583605 hasConceptScore W2000583605C120770815 @default.
• W2000583605 hasConceptScore W2000583605C126322002 @default.
• W2000583605 hasConceptScore W2000583605C139940330 @default.

• next