FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000584621> ?p ?o ?g. }

• W2000584621 endingPage "1023" @default.
• W2000584621 startingPage "1010" @default.
• W2000584621 abstract "Three monomers with 1,3-dicarboxylate functional groups but varying spacer lengths were synthesized via carbon Michael addition using malonate esters and ethylene- (MAETC), butylene- (MABTC), and hexylene (MAHTC) glycol dimethacrylate, respectively. Poly[oligo-(ethylene glycol) methylether methacrylate] (POEGMEMA) was prepared in the presence of a RAFT (reversible addition–fragmentation chain transfer) agent, followed by chain extension with the prepared monomers to generate three different block copolymers (BP-E80, BP-B82, and BP-H79) with similar numbers of repeating units, but various spacer lengths as distinguishing features. Conjugation with platinum drugs created macromolecular platinum drugs resembling carboplatin. The amphiphilic natures of these Pt-containing block copolymers led to the formation micelles in solution. The rate of drug release of all micelles was similar, but a noticeable difference was the increasing stability of the micelle against dissociation with increasing spacer length. The platinum conjugated polymer showed high activity against A549, OVCAR3, and SKOV3 cancer cell lines exceeding the activity of carboplatin, but only the micelle based on the longest spacer had IC50 values as low as cisplatin. Cellular uptake studies identified a better micelle uptake with increasing micelle stability as a possible reason for lower IC50 values. The clonogenic assay revealed that micelles loaded with platinum drugs, in contrast to low molecular weight carboplatin, have not only better activity within the frame of a 72 h cell viability study, but also display a longer lasting effect by preventing the colony formation A549 for more than 10 days." @default.
• W2000584621 created "2016-06-24" @default.
• W2000584621 creator A5016059121 @default.
• W2000584621 creator A5023489689 @default.
• W2000584621 creator A5034573171 @default.
• W2000584621 creator A5053187905 @default.
• W2000584621 date "2012-02-29" @default.
• W2000584621 modified "2023-10-11" @default.
• W2000584621 title "Block Copolymer Micelles with Pendant Bifunctional Chelator for Platinum Drugs: Effect of Spacer Length on the Viability of Tumor Cells" @default.
• W2000584621 cites W169184282 @default.
• W2000584621 cites W1968197734 @default.
• W2000584621 cites W1970343501 @default.
• W2000584621 cites W1973294617 @default.
• W2000584621 cites W1974123162 @default.
• W2000584621 cites W1978317679 @default.
• W2000584621 cites W1980381802 @default.
• W2000584621 cites W1980411311 @default.
• W2000584621 cites W1982379994 @default.
• W2000584621 cites W1983106473 @default.
• W2000584621 cites W1984365115 @default.
• W2000584621 cites W1985037778 @default.
• W2000584621 cites W1987559294 @default.
• W2000584621 cites W1988824901 @default.
• W2000584621 cites W1988840055 @default.
• W2000584621 cites W1992972854 @default.
• W2000584621 cites W1993053769 @default.
• W2000584621 cites W1997213816 @default.
• W2000584621 cites W2005483990 @default.
• W2000584621 cites W2006413291 @default.
• W2000584621 cites W2012108057 @default.
• W2000584621 cites W2015346163 @default.
• W2000584621 cites W2022173743 @default.
• W2000584621 cites W2023868317 @default.
• W2000584621 cites W2024565349 @default.
• W2000584621 cites W2028940434 @default.
• W2000584621 cites W2029596912 @default.
• W2000584621 cites W2029802083 @default.
• W2000584621 cites W2031942155 @default.
• W2000584621 cites W2034081467 @default.
• W2000584621 cites W2034509936 @default.
• W2000584621 cites W2037804186 @default.
• W2000584621 cites W2041066195 @default.
• W2000584621 cites W2048909233 @default.
• W2000584621 cites W2050293461 @default.
• W2000584621 cites W2055321318 @default.
• W2000584621 cites W2057068506 @default.
• W2000584621 cites W2068809055 @default.
• W2000584621 cites W2069041300 @default.
• W2000584621 cites W2070169944 @default.
• W2000584621 cites W2071756286 @default.
• W2000584621 cites W2072557746 @default.
• W2000584621 cites W2075960393 @default.
• W2000584621 cites W2076966327 @default.
• W2000584621 cites W2080896481 @default.
• W2000584621 cites W2081284509 @default.
• W2000584621 cites W2082105104 @default.
• W2000584621 cites W2086584469 @default.
• W2000584621 cites W2090549309 @default.
• W2000584621 cites W2093282189 @default.
• W2000584621 cites W2108834534 @default.
• W2000584621 cites W2109689528 @default.
• W2000584621 cites W2111570380 @default.
• W2000584621 cites W2130177169 @default.
• W2000584621 cites W2132834292 @default.
• W2000584621 cites W2135227850 @default.
• W2000584621 cites W2153691074 @default.
• W2000584621 cites W2159701130 @default.
• W2000584621 cites W2166157304 @default.
• W2000584621 cites W2323399103 @default.
• W2000584621 cites W2325543066 @default.
• W2000584621 cites W2480689621 @default.
• W2000584621 cites W2951440459 @default.
• W2000584621 cites W78319162 @default.
• W2000584621 cites W996626411 @default.
• W2000584621 cites W2115351737 @default.
• W2000584621 doi "https://doi.org/10.1021/bm2017299" @default.
• W2000584621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22324363" @default.
• W2000584621 hasPublicationYear "2012" @default.
• W2000584621 type Work @default.
• W2000584621 sameAs 2000584621 @default.
• W2000584621 citedByCount "71" @default.
• W2000584621 countsByYear W20005846212012 @default.
• W2000584621 countsByYear W20005846212013 @default.
• W2000584621 countsByYear W20005846212014 @default.
• W2000584621 countsByYear W20005846212015 @default.
• W2000584621 countsByYear W20005846212016 @default.
• W2000584621 countsByYear W20005846212017 @default.
• W2000584621 countsByYear W20005846212018 @default.
• W2000584621 countsByYear W20005846212019 @default.
• W2000584621 countsByYear W20005846212020 @default.
• W2000584621 countsByYear W20005846212021 @default.
• W2000584621 countsByYear W20005846212022 @default.
• W2000584621 crossrefType "journal-article" @default.
• W2000584621 hasAuthorship W2000584621A5016059121 @default.
• W2000584621 hasAuthorship W2000584621A5023489689 @default.
• W2000584621 hasAuthorship W2000584621A5034573171 @default.
• W2000584621 hasAuthorship W2000584621A5053187905 @default.
• W2000584621 hasConcept C111998727 @default.

• next