Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000585573> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2000585573 endingPage "87" @default.
- W2000585573 startingPage "82" @default.
- W2000585573 abstract "In 19 asthmatic children aged 6-16 years, the degree of bronchial hyperreactivity was determined in relationship to the concentration of inhaled histamine which caused a fall of the specific conductance (sGaw) to 60% of the baseline value PC60sGaw. At the time of lung function testing, a sample of heparinized blood was obtained from each patient. Eosinophils were purified and separated into a normodense and hypodense fraction by Percoll gradient centrifugation. After in vitro stimulation by ionophore A 23187, the leukotriene C4 (LTC4) content was determined in the culture supernatants. Hypodense eosinophils of the 13 children with a histamine threshold lower than 1 mg/ml generated significantly (p less than 0.01) larger amounts of LTC4 (0.8-36.3 ng/10(6) cells) when compared to 6 children with a histamine threshold higher than 1 mg/ml (0.7-12.1 ng/10(6) cells) and 12 healthy controls (0.4-8.2 ng/10(6) cells). Preincubation of eosinophils with platelet activating factor (PAF) induced an enhanced LTC4 production, not only in hypodense cells from both asthmatic groups but also in normodense cells from patients with severe hyperresponsiveness. These results are consistent with other results which suggest an important role of eosinophils, their activation by PAF and enhanced release of spasmogenic LTC4 in the pathogenesis of asthma." @default.
- W2000585573 created "2016-06-24" @default.
- W2000585573 creator A5001336776 @default.
- W2000585573 creator A5014763669 @default.
- W2000585573 creator A5016829123 @default.
- W2000585573 creator A5057800498 @default.
- W2000585573 creator A5061881859 @default.
- W2000585573 creator A5065690855 @default.
- W2000585573 date "1990-01-01" @default.
- W2000585573 modified "2023-09-26" @default.
- W2000585573 title "Relationship between LTC<sub>4</sub> Generation of Hypodense Eosinophils and Bronchial Hyperreactivity in Asthmatic Children" @default.
- W2000585573 doi "https://doi.org/10.1159/000235229" @default.
- W2000585573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2246079" @default.
- W2000585573 hasPublicationYear "1990" @default.
- W2000585573 type Work @default.
- W2000585573 sameAs 2000585573 @default.
- W2000585573 citedByCount "14" @default.
- W2000585573 countsByYear W20005855732013 @default.
- W2000585573 crossrefType "journal-article" @default.
- W2000585573 hasAuthorship W2000585573A5001336776 @default.
- W2000585573 hasAuthorship W2000585573A5014763669 @default.
- W2000585573 hasAuthorship W2000585573A5016829123 @default.
- W2000585573 hasAuthorship W2000585573A5057800498 @default.
- W2000585573 hasAuthorship W2000585573A5061881859 @default.
- W2000585573 hasAuthorship W2000585573A5065690855 @default.
- W2000585573 hasConcept C1122143 @default.
- W2000585573 hasConcept C126322002 @default.
- W2000585573 hasConcept C134018914 @default.
- W2000585573 hasConcept C185592680 @default.
- W2000585573 hasConcept C202751555 @default.
- W2000585573 hasConcept C203014093 @default.
- W2000585573 hasConcept C2776042228 @default.
- W2000585573 hasConcept C2776178081 @default.
- W2000585573 hasConcept C2776238763 @default.
- W2000585573 hasConcept C2776452501 @default.
- W2000585573 hasConcept C2777242621 @default.
- W2000585573 hasConcept C2777714996 @default.
- W2000585573 hasConcept C2779020240 @default.
- W2000585573 hasConcept C2779543280 @default.
- W2000585573 hasConcept C2780769369 @default.
- W2000585573 hasConcept C48679268 @default.
- W2000585573 hasConcept C55493867 @default.
- W2000585573 hasConcept C71924100 @default.
- W2000585573 hasConceptScore W2000585573C1122143 @default.
- W2000585573 hasConceptScore W2000585573C126322002 @default.
- W2000585573 hasConceptScore W2000585573C134018914 @default.
- W2000585573 hasConceptScore W2000585573C185592680 @default.
- W2000585573 hasConceptScore W2000585573C202751555 @default.
- W2000585573 hasConceptScore W2000585573C203014093 @default.
- W2000585573 hasConceptScore W2000585573C2776042228 @default.
- W2000585573 hasConceptScore W2000585573C2776178081 @default.
- W2000585573 hasConceptScore W2000585573C2776238763 @default.
- W2000585573 hasConceptScore W2000585573C2776452501 @default.
- W2000585573 hasConceptScore W2000585573C2777242621 @default.
- W2000585573 hasConceptScore W2000585573C2777714996 @default.
- W2000585573 hasConceptScore W2000585573C2779020240 @default.
- W2000585573 hasConceptScore W2000585573C2779543280 @default.
- W2000585573 hasConceptScore W2000585573C2780769369 @default.
- W2000585573 hasConceptScore W2000585573C48679268 @default.
- W2000585573 hasConceptScore W2000585573C55493867 @default.
- W2000585573 hasConceptScore W2000585573C71924100 @default.
- W2000585573 hasIssue "1" @default.
- W2000585573 hasLocation W20005855731 @default.
- W2000585573 hasLocation W20005855732 @default.
- W2000585573 hasOpenAccess W2000585573 @default.
- W2000585573 hasPrimaryLocation W20005855731 @default.
- W2000585573 hasRelatedWork W1989272799 @default.
- W2000585573 hasRelatedWork W2000585573 @default.
- W2000585573 hasRelatedWork W2051135051 @default.
- W2000585573 hasRelatedWork W2053007269 @default.
- W2000585573 hasRelatedWork W2069405591 @default.
- W2000585573 hasRelatedWork W2070543943 @default.
- W2000585573 hasRelatedWork W2074951682 @default.
- W2000585573 hasRelatedWork W2300080217 @default.
- W2000585573 hasRelatedWork W2406146003 @default.
- W2000585573 hasRelatedWork W2475362125 @default.
- W2000585573 hasVolume "92" @default.
- W2000585573 isParatext "false" @default.
- W2000585573 isRetracted "false" @default.
- W2000585573 magId "2000585573" @default.
- W2000585573 workType "article" @default.