Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000586596> ?p ?o ?g. }
- W2000586596 endingPage "225" @default.
- W2000586596 startingPage "221" @default.
- W2000586596 abstract "The literature on idiopathic schizophrenia has consistently reported that poor premorbid functioning precedes onset of psychosis. Individuals with 22q11.2 deletion syndrome (22q11.2DS) are at heightened risk of developing schizophrenia. The present study examined the relationship between adult-onset schizophrenia and social and academic functioning across childhood and early adolescent development in 22q11.2DS. Premorbid adjustment in social and academic domains during childhood (ages 5–11 years) and early adolescence (ages 12–15 years) of 103 adults with 22q11.2DS was assessed using the Premorbid Adjustment Scale (PAS). Linear mixed-models were used to compare PAS scores between the 43 subjects who later developed schizophrenia and the 60 subjects who did not. Social functioning and academic functioning deteriorated from childhood to early adolescence among those who later developed schizophrenia compared to stable functioning, on average, in those who did not later develop a psychotic disorder. Those who developed schizophrenia had significantly higher PAS scores (indicating poorer functioning) in social (β = 0.118, 95% CI: 0.046–0.189) and academic (β = 0.072, 95% CI: 0.015–0.129) domains between childhood and early adolescence, independent of the presence of intellectual disability. The two groups had similar PAS scores during childhood. Consistent with the literature on idiopathic schizophrenia, deterioration in social and academic functioning between childhood and early adolescence preceded onset of schizophrenia in this cohort of 22q11.2DS patients, regardless of functioning at baseline. These findings suggest that monitoring for changes in functioning, in addition to emergence of typical symptoms, may help to prevent delays in diagnosis and treatment of major psychotic illness in 22q11.2DS." @default.
- W2000586596 created "2016-06-24" @default.
- W2000586596 creator A5010902712 @default.
- W2000586596 creator A5048228396 @default.
- W2000586596 creator A5071965611 @default.
- W2000586596 creator A5085885383 @default.
- W2000586596 date "2013-12-01" @default.
- W2000586596 modified "2023-09-25" @default.
- W2000586596 title "Premorbid adjustment and schizophrenia in individuals with 22q11.2 deletion syndrome" @default.
- W2000586596 cites W1532157360 @default.
- W2000586596 cites W1949681809 @default.
- W2000586596 cites W1970873231 @default.
- W2000586596 cites W1977161615 @default.
- W2000586596 cites W1980850343 @default.
- W2000586596 cites W1983623341 @default.
- W2000586596 cites W2001665113 @default.
- W2000586596 cites W2004469734 @default.
- W2000586596 cites W2007163693 @default.
- W2000586596 cites W2009995715 @default.
- W2000586596 cites W2016014060 @default.
- W2000586596 cites W2021106046 @default.
- W2000586596 cites W2040159013 @default.
- W2000586596 cites W2042869189 @default.
- W2000586596 cites W2062525878 @default.
- W2000586596 cites W2068398512 @default.
- W2000586596 cites W2075612749 @default.
- W2000586596 cites W2076209584 @default.
- W2000586596 cites W2082535164 @default.
- W2000586596 cites W2095406825 @default.
- W2000586596 cites W2099235089 @default.
- W2000586596 cites W2102329283 @default.
- W2000586596 cites W2106131962 @default.
- W2000586596 cites W2107506821 @default.
- W2000586596 cites W2109810791 @default.
- W2000586596 cites W2117939261 @default.
- W2000586596 cites W2121457685 @default.
- W2000586596 cites W2129863218 @default.
- W2000586596 cites W2132189464 @default.
- W2000586596 cites W2135934912 @default.
- W2000586596 cites W2144556506 @default.
- W2000586596 cites W2145338499 @default.
- W2000586596 cites W2151740301 @default.
- W2000586596 cites W2154166087 @default.
- W2000586596 cites W2163510652 @default.
- W2000586596 cites W2332443125 @default.
- W2000586596 cites W4211063728 @default.
- W2000586596 doi "https://doi.org/10.1016/j.schres.2013.10.041" @default.
- W2000586596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24262682" @default.
- W2000586596 hasPublicationYear "2013" @default.
- W2000586596 type Work @default.
- W2000586596 sameAs 2000586596 @default.
- W2000586596 citedByCount "21" @default.
- W2000586596 countsByYear W20005865962014 @default.
- W2000586596 countsByYear W20005865962015 @default.
- W2000586596 countsByYear W20005865962016 @default.
- W2000586596 countsByYear W20005865962017 @default.
- W2000586596 countsByYear W20005865962019 @default.
- W2000586596 countsByYear W20005865962020 @default.
- W2000586596 countsByYear W20005865962021 @default.
- W2000586596 countsByYear W20005865962023 @default.
- W2000586596 crossrefType "journal-article" @default.
- W2000586596 hasAuthorship W2000586596A5010902712 @default.
- W2000586596 hasAuthorship W2000586596A5048228396 @default.
- W2000586596 hasAuthorship W2000586596A5071965611 @default.
- W2000586596 hasAuthorship W2000586596A5085885383 @default.
- W2000586596 hasConcept C118552586 @default.
- W2000586596 hasConcept C126322002 @default.
- W2000586596 hasConcept C138496976 @default.
- W2000586596 hasConcept C139265228 @default.
- W2000586596 hasConcept C15744967 @default.
- W2000586596 hasConcept C167925730 @default.
- W2000586596 hasConcept C169900460 @default.
- W2000586596 hasConcept C205545832 @default.
- W2000586596 hasConcept C2776412080 @default.
- W2000586596 hasConcept C2779727114 @default.
- W2000586596 hasConcept C2992104508 @default.
- W2000586596 hasConcept C70410870 @default.
- W2000586596 hasConcept C71924100 @default.
- W2000586596 hasConcept C72563966 @default.
- W2000586596 hasConceptScore W2000586596C118552586 @default.
- W2000586596 hasConceptScore W2000586596C126322002 @default.
- W2000586596 hasConceptScore W2000586596C138496976 @default.
- W2000586596 hasConceptScore W2000586596C139265228 @default.
- W2000586596 hasConceptScore W2000586596C15744967 @default.
- W2000586596 hasConceptScore W2000586596C167925730 @default.
- W2000586596 hasConceptScore W2000586596C169900460 @default.
- W2000586596 hasConceptScore W2000586596C205545832 @default.
- W2000586596 hasConceptScore W2000586596C2776412080 @default.
- W2000586596 hasConceptScore W2000586596C2779727114 @default.
- W2000586596 hasConceptScore W2000586596C2992104508 @default.
- W2000586596 hasConceptScore W2000586596C70410870 @default.
- W2000586596 hasConceptScore W2000586596C71924100 @default.
- W2000586596 hasConceptScore W2000586596C72563966 @default.
- W2000586596 hasIssue "1-3" @default.
- W2000586596 hasLocation W20005865961 @default.
- W2000586596 hasLocation W20005865962 @default.
- W2000586596 hasOpenAccess W2000586596 @default.
- W2000586596 hasPrimaryLocation W20005865961 @default.