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- W2000587059 abstract "Tartrazine is an artificial azo dye commonly used in food products. The present study evaluated the interaction of tartrazine with two serum albumins (SAs), human serum albumin (HSA) and bovine serum albumin (BSA), under physiological conditions by means of fluorescence, three-dimensional fluorescence, UV-vis absorption, and circular dichroism (CD) techniques. The fluorescence data showed that tartrazine could bind to the two SAs to form a complex. The binding process was a spontaneous molecular interaction procedure, in which van der Waals and hydrogen bond interactions played a major role. Additionally, as shown by the UV-vis absorption, three-dimensional fluorescence, and CD results, tartrazine could lead to conformational and some microenvironmental changes of both SAs, which may affect the physiological functions of SAs. The work provides important insight into the mechanism of toxicity of tartrazine in vivo." @default.
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- W2000587059 date "2011-05-18" @default.
- W2000587059 modified "2023-09-29" @default.
- W2000587059 title "Characterizing the Interaction between Tartrazine and Two Serum Albumins by a Hybrid Spectroscopic Approach" @default.
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- W2000587059 doi "https://doi.org/10.1021/jf200907x" @default.
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