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- W2000587364 abstract "Equations were derived to describe the transport rate of a solute from an aqueous environment to an oil phase present as finely dispersed droplets. The basic diffusion equations included the effects of micellar solubilization in the aqueous phase and an interfacial barrier at the o/w interface. Two separate experimental systems were evaluated by fitting data to the rates predicted theo-retically. System I was composed of polysorbate 80 as the surfactant, isopropyl myristate as the oil phase, and 2,3-bis-(p-methoxyphenyl)-indole as the drug solute. The second system was composed of mineral oil as the “sink”, dibutyl phthalate as the solute, and polysorbate 80. The aqueous phase of System II contained 75% sucrose to increase the viscosity. The experimental transport rates of the solutes most closely fit the rates predicted by the theory which assumes that an interfacial barrier was rate determining." @default.
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- W2000587364 date "1969-11-01" @default.
- W2000587364 modified "2023-09-24" @default.
- W2000587364 title "Mechanisms of Interphase Transport II: Theoretical Considerations and Experimental Evaluation of Interfacially Controlled Transport in Solubilized Systems" @default.
- W2000587364 cites W2014661533 @default.
- W2000587364 doi "https://doi.org/10.1002/jps.2600581109" @default.
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