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- W2000587580 abstract "Early in female mammalian embryogenesis, one of the two X chromosomes is inactivated to compensate the gene dosage between males and females. One of the features of X chromosome inactivation (XCI) is the late replication of the inactivated X chromosome. This study reports the identification, by competitive PCR of nascent DNA, of a replication origin in intron 2 of the human X-linked HPRT gene, that is functional only on the inactive X. Features frequently associated with replication origins, including a peak of enhanced DNA flexibility, a perfect match to the yeast ACS sequence, a 14/15 match to the Drosophila topoisomerase II consensus, and a 20/21 match to an initiation region consensus sequence, were identified close to the replication origin. The origin is located approximately 2 kb upstream of a matrix attachment region (MAR) and also contains two A:T-rich elements, thought to facilitate DNA unwinding. © 2005 Wiley-Liss, Inc." @default.
- W2000587580 created "2016-06-24" @default.
- W2000587580 creator A5015976204 @default.
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- W2000587580 date "2005-01-01" @default.
- W2000587580 modified "2023-09-26" @default.
- W2000587580 title "An inactive X specific replication origin associated with a matrix attachment region in the human X linkedHPRT gene" @default.
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- W2000587580 doi "https://doi.org/10.1002/jcb.20425" @default.
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