FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000588461> ?p ?o ?g. }

• W2000588461 endingPage "357" @default.
• W2000588461 startingPage "347" @default.
• W2000588461 abstract "Left ventricular hypertrophy (LVH), a common consequence of systemic hypertension associated with poor clinical outcome, is also a potentially reversible condition. Here, we probed the molecular pathways that underpin the development of LVH and their modulation by antihypertensive regimens that reversed LVH. Spontaneously hypertensive rats were studied at 12 (early LVH) and 48 weeks (late LVH), respectively, with normotensive Wistar-Kyoto rats as age-matched controls. Three treatment groups were maintained for 36 weeks on the following regimens: (1) quinapril, (2) doxazosin and quinapril combination, and (3) losartan. Gene expression profiling was performed with Affymetrix microarrays (GeneChip Rat-230A) and primary function-focused average linkage hierarchical cluster analysis. Of the 15 696 gene sequences expressed on the Affymetrix GeneChip Rat-230A, there was significant alteration in the expression of 295 (1.9%) of these transcripts in 'early' LVH and 143 (0.9%) in 'late' LVH. The predominant changes in gene expression were seen in metabolism, cell growth/proliferation, signal transduction, development and muscle contraction/cytoskeleton functional groups. Although sharing many effects on gene expression, the three treatments showed different expression profiles. Despite significant regression of LVH with treatment, 31 LVH-associated transcripts were unchanged by any of the treatment groups. Our data suggest that LVH regression does not normalize the LVH transcriptome. Therefore, regression of hypertension-induced LVH is associated with a distinct gene expression profile, suggesting the effect of both treatment and a previously unknown specific myocardial physiology after regression of LVH." @default.
• W2000588461 created "2016-06-24" @default.
• W2000588461 creator A5001453005 @default.
• W2000588461 creator A5003754642 @default.
• W2000588461 creator A5005804630 @default.
• W2000588461 creator A5029781695 @default.
• W2000588461 creator A5043010855 @default.
• W2000588461 creator A5049852436 @default.
• W2000588461 creator A5051933177 @default.
• W2000588461 creator A5066877606 @default.
• W2000588461 creator A5068483716 @default.
• W2000588461 creator A5069797611 @default.
• W2000588461 date "2009-03-27" @default.
• W2000588461 modified "2023-10-10" @default.
• W2000588461 title "Transcriptome of hypertension-induced left ventricular hypertrophy and its regression by antihypertensive therapies" @default.
• W2000588461 cites W1534224609 @default.
• W2000588461 cites W1552118263 @default.
• W2000588461 cites W1599321131 @default.
• W2000588461 cites W1965612542 @default.
• W2000588461 cites W196745860 @default.
• W2000588461 cites W1968202984 @default.
• W2000588461 cites W1968661531 @default.
• W2000588461 cites W1968994105 @default.
• W2000588461 cites W1969367924 @default.
• W2000588461 cites W1969437309 @default.
• W2000588461 cites W1973471948 @default.
• W2000588461 cites W1974948854 @default.
• W2000588461 cites W1984335970 @default.
• W2000588461 cites W1989627988 @default.
• W2000588461 cites W1992217162 @default.
• W2000588461 cites W1994925305 @default.
• W2000588461 cites W1998198047 @default.
• W2000588461 cites W2000320582 @default.
• W2000588461 cites W2003888925 @default.
• W2000588461 cites W2006224306 @default.
• W2000588461 cites W2008434058 @default.
• W2000588461 cites W2011451357 @default.
• W2000588461 cites W2023039109 @default.
• W2000588461 cites W2037319942 @default.
• W2000588461 cites W2058927719 @default.
• W2000588461 cites W2063836440 @default.
• W2000588461 cites W2068061415 @default.
• W2000588461 cites W2076905917 @default.
• W2000588461 cites W2080477342 @default.
• W2000588461 cites W2081557597 @default.
• W2000588461 cites W2082461149 @default.
• W2000588461 cites W2082800364 @default.
• W2000588461 cites W2084937324 @default.
• W2000588461 cites W2093801383 @default.
• W2000588461 cites W2094138142 @default.
• W2000588461 cites W2107025256 @default.
• W2000588461 cites W2108477432 @default.
• W2000588461 cites W2111344235 @default.
• W2000588461 cites W2116091611 @default.
• W2000588461 cites W2121370344 @default.
• W2000588461 cites W2122808924 @default.
• W2000588461 cites W2125537604 @default.
• W2000588461 cites W2129439677 @default.
• W2000588461 cites W2132136466 @default.
• W2000588461 cites W2132454291 @default.
• W2000588461 cites W2136070250 @default.
• W2000588461 cites W2139084975 @default.
• W2000588461 cites W2146851676 @default.
• W2000588461 cites W2149007627 @default.
• W2000588461 cites W2150926065 @default.
• W2000588461 cites W2153283433 @default.
• W2000588461 cites W2157703656 @default.
• W2000588461 cites W2157870057 @default.
• W2000588461 cites W2169054761 @default.
• W2000588461 cites W2171908036 @default.
• W2000588461 doi "https://doi.org/10.1038/hr.2009.27" @default.
• W2000588461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19325563" @default.
• W2000588461 hasPublicationYear "2009" @default.
• W2000588461 type Work @default.
• W2000588461 sameAs 2000588461 @default.
• W2000588461 citedByCount "10" @default.
• W2000588461 countsByYear W20005884612013 @default.
• W2000588461 countsByYear W20005884612014 @default.
• W2000588461 countsByYear W20005884612015 @default.
• W2000588461 countsByYear W20005884612016 @default.
• W2000588461 countsByYear W20005884612017 @default.
• W2000588461 countsByYear W20005884612018 @default.
• W2000588461 countsByYear W20005884612020 @default.
• W2000588461 countsByYear W20005884612021 @default.
• W2000588461 crossrefType "journal-article" @default.
• W2000588461 hasAuthorship W2000588461A5001453005 @default.
• W2000588461 hasAuthorship W2000588461A5003754642 @default.
• W2000588461 hasAuthorship W2000588461A5005804630 @default.
• W2000588461 hasAuthorship W2000588461A5029781695 @default.
• W2000588461 hasAuthorship W2000588461A5043010855 @default.
• W2000588461 hasAuthorship W2000588461A5049852436 @default.
• W2000588461 hasAuthorship W2000588461A5051933177 @default.
• W2000588461 hasAuthorship W2000588461A5066877606 @default.
• W2000588461 hasAuthorship W2000588461A5068483716 @default.
• W2000588461 hasAuthorship W2000588461A5069797611 @default.
• W2000588461 hasBestOaLocation W20005884611 @default.
• W2000588461 hasConcept C104317684 @default.
• W2000588461 hasConcept C126322002 @default.

• next