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- W2000588685 abstract "An original way to manage both stereochemistry and conformational constraints in ligand candidates for bioassays is presented with reference to a group of model N,N′-tetrasubstituted o-phthalamides and thioamides. The study shows that a scale of thermal flexibility in solution can be envisaged, the divisions of which are represented by compounds sharing quite similar geometrical features. NMR spectroscopy and powder X-ray analysis were used for the physical chemical investigation. An attempt to exploit the conformational instability of a model thioamide in the medium of a bioassay was also performed." @default.
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- W2000588685 date "2006-07-01" @default.
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- W2000588685 title "A way to manage the thermal flexibility of ligand candidates for bioassays" @default.
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- W2000588685 doi "https://doi.org/10.1016/j.tet.2006.05.011" @default.
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