FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000589316> ?p ?o ?g. }

• W2000589316 endingPage "80" @default.
• W2000589316 startingPage "75" @default.
• W2000589316 abstract "DOPAMINE is stored in specific neurons of the central nervous system,l where it in all probability plays a role as a, transmitter substance. Dopamine is formed from dietary tyrosine and it is metabolized to homovanillic acid @WA), which appears to be the major metabolite leaving the central nervous system (Fig. 1). From experiments in animals there is evidence that antipsychotic drugs markedly accelerate brain dopamine synthesis. Thus, following administration of chlorpromazine and haloperidol, levels of the dopamine metabolites, 3-methoxy-tyramine and HVA, are markedly elevated.2*3 The effects of drugs ‘on brain dopamine metabolism can also be studied using 14C-tyrosine as a tool. In a series of papers we have demonstrated that antipsychotic drugs belonging to the phenothiazine, thioxanthene, butyrophenone and dibenzoazepine series, all markedly accelerate synthesis as well as turnover of dopamine formed from 14C-tyrosine in the brain of rats and mice.4-6 It is evident from Table 1 that all the compounds tested, with the exception of promethazine which is a non-neuroleptic phenothiazine analogue, accelerate 14C-dopamine synthesis in brain of mice. Effects on 14C-noradrenaline are less consistent. Since such an acceleration of brain dopamine metabolism is not produced by other groups of psychoactive drugs as sedatives, antidepressants, central stimulants or hallucinogens,’ it appears likely that the acceleration of brain dopamine synthesis induced by neuroleptics is related to their antipsychotic efficacy.6,s The relatively specific effect of chlorpromazine and related neuroleptic drugs on schizophrenic behaviour,g and the demonstration of their marked effects on brain dopamine metabolism, suggested a role for dopamine in the pathophysiology of schizophrenia.10-12 Since the doses of neuroleptics required to accelerate brain dopamine synthesis in animals are comparable to those used for treatment of schizophrenia in patients, one would also expect brain dopamine synthesis in the human brain to be markedly increased during treatment with neuroleptic drugs. This would also be expected if the antipsychotic efficacy of neuroleptics is related to an acceleration of brain dopamine synthesis. The evidence for the effects of neuroleptics on human brain dopamine metabolism is highly ambiguous .13 This may be due partly to the previous use of fluorimetric methods" @default.
• W2000589316 created "2016-06-24" @default.
• W2000589316 creator A5013806197 @default.
• W2000589316 creator A5057429930 @default.
• W2000589316 creator A5065480604 @default.
• W2000589316 creator A5080176381 @default.
• W2000589316 creator A5086956119 @default.
• W2000589316 date "1974-01-01" @default.
• W2000589316 modified "2023-10-16" @default.
• W2000589316 title "Mass fragmentometric determination of homovanillic acid in lumbar cerebro-spinal fluid of schizophrenic patients during treatment with antipsychotic drugs" @default.
• W2000589316 cites W1991556176 @default.
• W2000589316 cites W2007437143 @default.
• W2000589316 cites W2015161406 @default.
• W2000589316 cites W2035936600 @default.
• W2000589316 cites W2043726286 @default.
• W2000589316 cites W2048911173 @default.
• W2000589316 cites W2051776206 @default.
• W2000589316 cites W2062984688 @default.
• W2000589316 cites W2078621792 @default.
• W2000589316 cites W2081357518 @default.
• W2000589316 cites W2081371398 @default.
• W2000589316 cites W2159996636 @default.
• W2000589316 cites W2162207365 @default.
• W2000589316 cites W2244658521 @default.
• W2000589316 cites W2400183593 @default.
• W2000589316 cites W2767410202 @default.
• W2000589316 doi "https://doi.org/10.1016/0022-3956(74)90075-2" @default.
• W2000589316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4461807" @default.
• W2000589316 hasPublicationYear "1974" @default.
• W2000589316 type Work @default.
• W2000589316 sameAs 2000589316 @default.
• W2000589316 citedByCount "58" @default.
• W2000589316 countsByYear W20005893162021 @default.
• W2000589316 crossrefType "journal-article" @default.
• W2000589316 hasAuthorship W2000589316A5013806197 @default.
• W2000589316 hasAuthorship W2000589316A5057429930 @default.
• W2000589316 hasAuthorship W2000589316A5065480604 @default.
• W2000589316 hasAuthorship W2000589316A5080176381 @default.
• W2000589316 hasAuthorship W2000589316A5086956119 @default.
• W2000589316 hasConcept C118552586 @default.
• W2000589316 hasConcept C126322002 @default.
• W2000589316 hasConcept C15744967 @default.
• W2000589316 hasConcept C170493617 @default.
• W2000589316 hasConcept C2775841634 @default.
• W2000589316 hasConcept C2775864247 @default.
• W2000589316 hasConcept C2776412080 @default.
• W2000589316 hasConcept C2780494398 @default.
• W2000589316 hasConcept C42219234 @default.
• W2000589316 hasConcept C71924100 @default.
• W2000589316 hasConceptScore W2000589316C118552586 @default.
• W2000589316 hasConceptScore W2000589316C126322002 @default.
• W2000589316 hasConceptScore W2000589316C15744967 @default.
• W2000589316 hasConceptScore W2000589316C170493617 @default.
• W2000589316 hasConceptScore W2000589316C2775841634 @default.
• W2000589316 hasConceptScore W2000589316C2775864247 @default.
• W2000589316 hasConceptScore W2000589316C2776412080 @default.
• W2000589316 hasConceptScore W2000589316C2780494398 @default.
• W2000589316 hasConceptScore W2000589316C42219234 @default.
• W2000589316 hasConceptScore W2000589316C71924100 @default.
• W2000589316 hasLocation W20005893161 @default.
• W2000589316 hasLocation W20005893162 @default.
• W2000589316 hasOpenAccess W2000589316 @default.
• W2000589316 hasPrimaryLocation W20005893161 @default.
• W2000589316 hasRelatedWork W1930318638 @default.
• W2000589316 hasRelatedWork W1964628752 @default.
• W2000589316 hasRelatedWork W1969521926 @default.
• W2000589316 hasRelatedWork W2044398915 @default.
• W2000589316 hasRelatedWork W2110640372 @default.
• W2000589316 hasRelatedWork W2292275194 @default.
• W2000589316 hasRelatedWork W2474679401 @default.
• W2000589316 hasRelatedWork W2601466518 @default.
• W2000589316 hasRelatedWork W3174036944 @default.
• W2000589316 hasRelatedWork W69027840 @default.
• W2000589316 hasVolume "11" @default.
• W2000589316 isParatext "false" @default.
• W2000589316 isRetracted "false" @default.
• W2000589316 magId "2000589316" @default.
• W2000589316 workType "article" @default.