Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000589785> ?p ?o ?g. }
- W2000589785 endingPage "614" @default.
- W2000589785 startingPage "606" @default.
- W2000589785 abstract "Airway secretions of cystic fibrosis patients were found to contain high concentrations of taurine, which decreased with antibiotic therapy during acute respiratory exacerbations. Taurine, in a 1:1 molar ratio with HOCl/OCl-, caused a 10-fold increase in the amount of HOCl/OCl- needed to induce cytotoxicity to the cat lung epithelial cell line, AKD. Although DMSO protected cells against HOCl/OCl(-)-mediated injury, the presence of an equimolar concentration of taurine with HOCl/OCl- prevented DMSO from protecting cells and sulfhydryl groups against oxidation, suggesting the formation of taurine chloramines. Spectral properties confirmed the formation of monochloramines and dichloramines. Chloride-free buffer, DIDS, and low temperature (4 degrees C) each protected the cells against taurine/HOCl/OCl-, indicating that taurine chloramine uptake through anion transport pathways was required to induce cytotoxicity. A molar excess of taurine inhibited cytotoxicity, to induce cytotoxicity. A molar excess of taurine inhibited cytotoxicity, by decreasing taurine dichloramines and increasing the formation of less toxic taurine monochloramines. We conclude that taurine can protect lung epithelial cells by converting HOCl/OCl- to anionic monochloramines, but that taurine dichloramines can be toxic to respiratory epithelial cells through mechanisms that depend upon epithelial cell anion transport." @default.
- W2000589785 created "2016-06-24" @default.
- W2000589785 creator A5052160402 @default.
- W2000589785 date "1994-02-01" @default.
- W2000589785 modified "2023-09-23" @default.
- W2000589785 title "Taurine modulation of hypochlorous acid-induced lung epithelial cell injury in vitro. Role of anion transport." @default.
- W2000589785 cites W1529776597 @default.
- W2000589785 cites W1607565236 @default.
- W2000589785 cites W1811725048 @default.
- W2000589785 cites W1972182067 @default.
- W2000589785 cites W1987261853 @default.
- W2000589785 cites W1990987230 @default.
- W2000589785 cites W1995614141 @default.
- W2000589785 cites W2006192600 @default.
- W2000589785 cites W2006370393 @default.
- W2000589785 cites W2016211631 @default.
- W2000589785 cites W2030631267 @default.
- W2000589785 cites W2039599894 @default.
- W2000589785 cites W2044594872 @default.
- W2000589785 cites W2044754685 @default.
- W2000589785 cites W2049914201 @default.
- W2000589785 cites W2051327380 @default.
- W2000589785 cites W2078078890 @default.
- W2000589785 cites W2079234445 @default.
- W2000589785 cites W2087884845 @default.
- W2000589785 cites W2098501605 @default.
- W2000589785 cites W2125391335 @default.
- W2000589785 cites W2127874341 @default.
- W2000589785 cites W2127920211 @default.
- W2000589785 cites W2129707656 @default.
- W2000589785 cites W2154563160 @default.
- W2000589785 cites W2173087970 @default.
- W2000589785 cites W2266521079 @default.
- W2000589785 cites W2290995940 @default.
- W2000589785 cites W2314880994 @default.
- W2000589785 cites W2330496924 @default.
- W2000589785 cites W2398144103 @default.
- W2000589785 cites W2400422495 @default.
- W2000589785 cites W2408922396 @default.
- W2000589785 cites W2411162231 @default.
- W2000589785 cites W2418910385 @default.
- W2000589785 cites W2462083512 @default.
- W2000589785 cites W2467490546 @default.
- W2000589785 cites W989016558 @default.
- W2000589785 doi "https://doi.org/10.1172/jci117013" @default.
- W2000589785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/293884" @default.
- W2000589785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8113398" @default.
- W2000589785 hasPublicationYear "1994" @default.
- W2000589785 type Work @default.
- W2000589785 sameAs 2000589785 @default.
- W2000589785 citedByCount "80" @default.
- W2000589785 countsByYear W20005897852012 @default.
- W2000589785 countsByYear W20005897852015 @default.
- W2000589785 countsByYear W20005897852017 @default.
- W2000589785 countsByYear W20005897852018 @default.
- W2000589785 countsByYear W20005897852019 @default.
- W2000589785 countsByYear W20005897852020 @default.
- W2000589785 countsByYear W20005897852021 @default.
- W2000589785 countsByYear W20005897852022 @default.
- W2000589785 countsByYear W20005897852023 @default.
- W2000589785 crossrefType "journal-article" @default.
- W2000589785 hasAuthorship W2000589785A5052160402 @default.
- W2000589785 hasBestOaLocation W20005897851 @default.
- W2000589785 hasConcept C109316439 @default.
- W2000589785 hasConcept C127160389 @default.
- W2000589785 hasConcept C185592680 @default.
- W2000589785 hasConcept C202751555 @default.
- W2000589785 hasConcept C2776853492 @default.
- W2000589785 hasConcept C2779701627 @default.
- W2000589785 hasConcept C2780908991 @default.
- W2000589785 hasConcept C515207424 @default.
- W2000589785 hasConcept C55493867 @default.
- W2000589785 hasConceptScore W2000589785C109316439 @default.
- W2000589785 hasConceptScore W2000589785C127160389 @default.
- W2000589785 hasConceptScore W2000589785C185592680 @default.
- W2000589785 hasConceptScore W2000589785C202751555 @default.
- W2000589785 hasConceptScore W2000589785C2776853492 @default.
- W2000589785 hasConceptScore W2000589785C2779701627 @default.
- W2000589785 hasConceptScore W2000589785C2780908991 @default.
- W2000589785 hasConceptScore W2000589785C515207424 @default.
- W2000589785 hasConceptScore W2000589785C55493867 @default.
- W2000589785 hasIssue "2" @default.
- W2000589785 hasLocation W20005897851 @default.
- W2000589785 hasLocation W20005897852 @default.
- W2000589785 hasLocation W20005897853 @default.
- W2000589785 hasLocation W20005897854 @default.
- W2000589785 hasOpenAccess W2000589785 @default.
- W2000589785 hasPrimaryLocation W20005897851 @default.
- W2000589785 hasRelatedWork W1531300780 @default.
- W2000589785 hasRelatedWork W1811725048 @default.
- W2000589785 hasRelatedWork W1902554899 @default.
- W2000589785 hasRelatedWork W2000589785 @default.
- W2000589785 hasRelatedWork W2102456450 @default.
- W2000589785 hasRelatedWork W2172023650 @default.
- W2000589785 hasRelatedWork W2749974173 @default.
- W2000589785 hasRelatedWork W2970281350 @default.
- W2000589785 hasRelatedWork W3010661076 @default.
- W2000589785 hasRelatedWork W2070911357 @default.