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• W2000589976 abstract "Very rare cases of human T cell acute lymphoblastic leukemia (T-ALL) harbor chromosomal translocations that involve NOTCH1, a gene encoding a transmembrane receptor that regulates normal T cell development. Here, we report that more than 50% of human T-ALLs, including tumors from all major molecular oncogenic subtypes, have activating mutations that involve the extracellular heterodimerization domain and/or the C-terminal PEST domain of NOTCH1. These findings greatly expand the role of activated NOTCH1 in the molecular pathogenesis of human T-ALL and provide a strong rationale for targeted therapies that interfere with NOTCH signaling." @default.
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• W2000589976 date "2004-10-08" @default.
• W2000589976 modified "2023-10-14" @default.
• W2000589976 title "Activating Mutations of <i>NOTCH1</i> in Human T Cell Acute Lymphoblastic Leukemia" @default.
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• W2000589976 doi "https://doi.org/10.1126/science.1102160" @default.
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