FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000589984> ?p ?o ?g. }

• W2000589984 endingPage "e66092" @default.
• W2000589984 startingPage "e66092" @default.
• W2000589984 abstract "As the main precursor for lactose synthesis, large amounts of glucose are required by lactating dairy cows. Milk yield greatly depends on mammary lactose synthesis due to its osmoregulatory property for mammary uptake of water. Thus, glucose availability to the mammary gland could be a potential regulator of milk production. In the present study, the effect of glucose availability on expression of the key genes involved in synthesis of milk fat, lactose and glucose metabolism in vitro was investigated. Bovine mammary epithelial cells (BMEC) were treated for 12 h with various concentrations of glucose (2.5, 5, 10 or 20 mmol/L). The higher concentrations of glucose (10-20 mmol/L) did not affect the mRNA expression of acetyl-CoA carboxylase, diacyl glycerol acyl transferase, glycerol-3 phosphate acyl transferase and α-lactalbumin, whereas fatty acid synthase, sterol regulatory element binding protein-1 and beta-1, 4-galactosyl transferase mRNA expression increased at 10 mmol/L and then decreased at 20 mmol/L. The content of lactose synthase increased with increasing concentration of glucose, with addition of highest value at 20 mmol/L of glucose. Moreover, the increased glucose concentration stimulated the activities of pyruvate kinase and glucose-6-phosphate dehydrogenase, and elevated the energy status of the BMEC. Therefore, it was deduced that after increasing glucose availability, the extra absorbed glucose was partitioned to entering the synthesis of milk fat and lactose by the regulation of the mRNA expression of key genes, promoting glucose metabolism by glycolysis and pentose phosphate pathway as well as energy status. These results indicated that the sufficient availability of glucose in BMEC may promote glucose metabolism, and affect the synthesis of milk composition." @default.
• W2000589984 created "2016-06-24" @default.
• W2000589984 creator A5012155031 @default.
• W2000589984 creator A5013814771 @default.
• W2000589984 creator A5074761778 @default.
• W2000589984 date "2013-06-14" @default.
• W2000589984 modified "2023-10-17" @default.
• W2000589984 title "Effects of Glucose Availability on Expression of the Key Genes Involved in Synthesis of Milk Fat, Lactose and Glucose Metabolism in Bovine Mammary Epithelial Cells" @default.
• W2000589984 cites W1503075767 @default.
• W2000589984 cites W1593579216 @default.
• W2000589984 cites W1969464989 @default.
• W2000589984 cites W1984065377 @default.
• W2000589984 cites W2011177481 @default.
• W2000589984 cites W2014525075 @default.
• W2000589984 cites W2021597697 @default.
• W2000589984 cites W2025116679 @default.
• W2000589984 cites W2025535111 @default.
• W2000589984 cites W2026021375 @default.
• W2000589984 cites W2032107866 @default.
• W2000589984 cites W2040566047 @default.
• W2000589984 cites W2058344238 @default.
• W2000589984 cites W2061168344 @default.
• W2000589984 cites W2072401279 @default.
• W2000589984 cites W2096894403 @default.
• W2000589984 cites W2097497704 @default.
• W2000589984 cites W2107277218 @default.
• W2000589984 cites W2112189902 @default.
• W2000589984 cites W2116233022 @default.
• W2000589984 cites W2116528979 @default.
• W2000589984 cites W2121422007 @default.
• W2000589984 cites W2124307313 @default.
• W2000589984 cites W2136887204 @default.
• W2000589984 cites W2141598854 @default.
• W2000589984 cites W2147108986 @default.
• W2000589984 cites W2157371286 @default.
• W2000589984 cites W2166992789 @default.
• W2000589984 cites W2169452547 @default.
• W2000589984 cites W2171142773 @default.
• W2000589984 cites W42038014 @default.
• W2000589984 cites W4205150875 @default.
• W2000589984 cites W4213399548 @default.
• W2000589984 cites W4294402008 @default.
• W2000589984 doi "https://doi.org/10.1371/journal.pone.0066092" @default.
• W2000589984 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3682949" @default.
• W2000589984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23799073" @default.
• W2000589984 hasPublicationYear "2013" @default.
• W2000589984 type Work @default.
• W2000589984 sameAs 2000589984 @default.
• W2000589984 citedByCount "39" @default.
• W2000589984 countsByYear W20005899842014 @default.
• W2000589984 countsByYear W20005899842015 @default.
• W2000589984 countsByYear W20005899842016 @default.
• W2000589984 countsByYear W20005899842017 @default.
• W2000589984 countsByYear W20005899842018 @default.
• W2000589984 countsByYear W20005899842019 @default.
• W2000589984 countsByYear W20005899842020 @default.
• W2000589984 countsByYear W20005899842021 @default.
• W2000589984 countsByYear W20005899842022 @default.
• W2000589984 countsByYear W20005899842023 @default.
• W2000589984 crossrefType "journal-article" @default.
• W2000589984 hasAuthorship W2000589984A5012155031 @default.
• W2000589984 hasAuthorship W2000589984A5013814771 @default.
• W2000589984 hasAuthorship W2000589984A5074761778 @default.
• W2000589984 hasBestOaLocation W20005899841 @default.
• W2000589984 hasConcept C126322002 @default.
• W2000589984 hasConcept C134018914 @default.
• W2000589984 hasConcept C141359234 @default.
• W2000589984 hasConcept C161573976 @default.
• W2000589984 hasConcept C17093226 @default.
• W2000589984 hasConcept C178617795 @default.
• W2000589984 hasConcept C20251656 @default.
• W2000589984 hasConcept C2776941171 @default.
• W2000589984 hasConcept C2777866211 @default.
• W2000589984 hasConcept C2778724459 @default.
• W2000589984 hasConcept C2779306644 @default.
• W2000589984 hasConcept C2780854706 @default.
• W2000589984 hasConcept C3409486 @default.
• W2000589984 hasConcept C4733338 @default.
• W2000589984 hasConcept C48289651 @default.
• W2000589984 hasConcept C543025807 @default.
• W2000589984 hasConcept C55493867 @default.
• W2000589984 hasConcept C62231903 @default.
• W2000589984 hasConcept C68863886 @default.
• W2000589984 hasConcept C71924100 @default.
• W2000589984 hasConcept C86803240 @default.
• W2000589984 hasConcept C89200155 @default.
• W2000589984 hasConceptScore W2000589984C126322002 @default.
• W2000589984 hasConceptScore W2000589984C134018914 @default.
• W2000589984 hasConceptScore W2000589984C141359234 @default.
• W2000589984 hasConceptScore W2000589984C161573976 @default.
• W2000589984 hasConceptScore W2000589984C17093226 @default.
• W2000589984 hasConceptScore W2000589984C178617795 @default.
• W2000589984 hasConceptScore W2000589984C20251656 @default.
• W2000589984 hasConceptScore W2000589984C2776941171 @default.
• W2000589984 hasConceptScore W2000589984C2777866211 @default.
• W2000589984 hasConceptScore W2000589984C2778724459 @default.
• W2000589984 hasConceptScore W2000589984C2779306644 @default.
• W2000589984 hasConceptScore W2000589984C2780854706 @default.

• next