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- W2000590149 abstract "The theories of drug-receptor interactions are extensively discussed on the basic assumtption, that potent cell-stimulating agents need to occupy only a small fraction of the total receptor concentration to generate maximal response of the effector cell [l-4] . This assumption implies the presence of a ‘receptor reserve’ and it founded in attempts to reduce the concentration of particular ligand receptors by means of irreversible blocking compounds. Frequently, the 2-halogenoethylamine Dibenamine has been used, according to the concept [5], that Dibenamine alkylates directly those smooth muscle cell receptors with which the drug itself must combine to produce a response [3,4,6]. Recently, this theory has been contradicted [7]. The supposition was made, that alkylsting agents produce nonspecific allosteric interactions with multiple binding sites of the rat jejunum. In studies on the parasympatholytic effects of quatemary pyridines on the isolated guinea pig ileum [8], a treatment with Dibenamine caused changes of the activities of some pyridines. These findings are not consistent with the elimination of a fraction of cholinergic receptors. They are linked to the assumption of allosteric effects as a consequence of the treatment by Dibenamine." @default.
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- W2000590149 date "1974-02-01" @default.
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- W2000590149 title "A novel approach to the questions of allosteric properties or a ‘receptor reserve’ of drug binding sites of intestinal smooth muscle cells" @default.
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- W2000590149 doi "https://doi.org/10.1016/0014-5793(74)80017-7" @default.
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