FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000590884> ?p ?o ?g. }

• W2000590884 endingPage "5163" @default.
• W2000590884 startingPage "5152" @default.
• W2000590884 abstract "The discovery of a novel class of inhibitors of cyclin dependent kinases (CDKs) is described. Starting from compound 1, showing good potency as inhibitor of CDKs but being poorly selective against a panel of serine-threonine and tyrosine kinases, new analogues were synthesized. Enhancement in selectivity, antiproliferative activity against A2780 human ovarian carcinoma cells, and optimization of the physical properties and pharmacokinetic profile led to the identification of highly potent and orally available compounds. Compound 28 (PHA-848125), which in the preclinical xenograft A2780 human ovarian carcinoma model showed good efficacy and was well tolerated upon repeated daily treatments, was identified as a drug candidate for further development. Compound 28 is currently undergoing phase I and phase II clinical trials." @default.
• W2000590884 created "2016-06-24" @default.
• W2000590884 creator A5007214576 @default.
• W2000590884 creator A5008691829 @default.
• W2000590884 creator A5010046439 @default.
• W2000590884 creator A5018177635 @default.
• W2000590884 creator A5018214424 @default.
• W2000590884 creator A5021457170 @default.
• W2000590884 creator A5023227792 @default.
• W2000590884 creator A5030295107 @default.
• W2000590884 creator A5031466676 @default.
• W2000590884 creator A5038055949 @default.
• W2000590884 creator A5040374292 @default.
• W2000590884 creator A5042529900 @default.
• W2000590884 creator A5044377393 @default.
• W2000590884 creator A5050537557 @default.
• W2000590884 creator A5052160114 @default.
• W2000590884 creator A5055242790 @default.
• W2000590884 creator A5057560316 @default.
• W2000590884 creator A5059263766 @default.
• W2000590884 creator A5060718032 @default.
• W2000590884 creator A5062495032 @default.
• W2000590884 creator A5072319898 @default.
• W2000590884 creator A5080881030 @default.
• W2000590884 creator A5085619076 @default.
• W2000590884 date "2009-07-15" @default.
• W2000590884 modified "2023-09-27" @default.
• W2000590884 title "Identification of <i>N</i>,1,4,4-Tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1<i>H</i>-pyrazolo[4,3-<i>h</i>]quinazoline-3-carboxamide (PHA-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor" @default.
• W2000590884 cites W1985389450 @default.
• W2000590884 cites W2007618242 @default.
• W2000590884 cites W2015728503 @default.
• W2000590884 cites W2024680115 @default.
• W2000590884 cites W2026491640 @default.
• W2000590884 cites W2040736465 @default.
• W2000590884 cites W2046024621 @default.
• W2000590884 cites W2079096219 @default.
• W2000590884 cites W2087944863 @default.
• W2000590884 cites W2128250278 @default.
• W2000590884 cites W2130147203 @default.
• W2000590884 cites W2132442840 @default.
• W2000590884 cites W2143786806 @default.
• W2000590884 cites W2149658883 @default.
• W2000590884 cites W2170613699 @default.
• W2000590884 doi "https://doi.org/10.1021/jm9006559" @default.
• W2000590884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19603809" @default.
• W2000590884 hasPublicationYear "2009" @default.
• W2000590884 type Work @default.
• W2000590884 sameAs 2000590884 @default.
• W2000590884 citedByCount "105" @default.
• W2000590884 countsByYear W20005908842012 @default.
• W2000590884 countsByYear W20005908842013 @default.
• W2000590884 countsByYear W20005908842014 @default.
• W2000590884 countsByYear W20005908842015 @default.
• W2000590884 countsByYear W20005908842016 @default.
• W2000590884 countsByYear W20005908842017 @default.
• W2000590884 countsByYear W20005908842018 @default.
• W2000590884 countsByYear W20005908842019 @default.
• W2000590884 countsByYear W20005908842020 @default.
• W2000590884 countsByYear W20005908842021 @default.
• W2000590884 countsByYear W20005908842022 @default.
• W2000590884 countsByYear W20005908842023 @default.
• W2000590884 crossrefType "journal-article" @default.
• W2000590884 hasAuthorship W2000590884A5007214576 @default.
• W2000590884 hasAuthorship W2000590884A5008691829 @default.
• W2000590884 hasAuthorship W2000590884A5010046439 @default.
• W2000590884 hasAuthorship W2000590884A5018177635 @default.
• W2000590884 hasAuthorship W2000590884A5018214424 @default.
• W2000590884 hasAuthorship W2000590884A5021457170 @default.
• W2000590884 hasAuthorship W2000590884A5023227792 @default.
• W2000590884 hasAuthorship W2000590884A5030295107 @default.
• W2000590884 hasAuthorship W2000590884A5031466676 @default.
• W2000590884 hasAuthorship W2000590884A5038055949 @default.
• W2000590884 hasAuthorship W2000590884A5040374292 @default.
• W2000590884 hasAuthorship W2000590884A5042529900 @default.
• W2000590884 hasAuthorship W2000590884A5044377393 @default.
• W2000590884 hasAuthorship W2000590884A5050537557 @default.
• W2000590884 hasAuthorship W2000590884A5052160114 @default.
• W2000590884 hasAuthorship W2000590884A5055242790 @default.
• W2000590884 hasAuthorship W2000590884A5057560316 @default.
• W2000590884 hasAuthorship W2000590884A5059263766 @default.
• W2000590884 hasAuthorship W2000590884A5060718032 @default.
• W2000590884 hasAuthorship W2000590884A5062495032 @default.
• W2000590884 hasAuthorship W2000590884A5072319898 @default.
• W2000590884 hasAuthorship W2000590884A5080881030 @default.
• W2000590884 hasAuthorship W2000590884A5085619076 @default.
• W2000590884 hasConcept C104317684 @default.
• W2000590884 hasConcept C112705442 @default.
• W2000590884 hasConcept C11960822 @default.
• W2000590884 hasConcept C124320809 @default.
• W2000590884 hasConcept C184235292 @default.
• W2000590884 hasConcept C185592680 @default.
• W2000590884 hasConcept C193042331 @default.
• W2000590884 hasConcept C202751555 @default.
• W2000590884 hasConcept C2775880066 @default.
• W2000590884 hasConcept C2776414213 @default.
• W2000590884 hasConcept C2778866207 @default.
• W2000590884 hasConcept C2780035454 @default.
• W2000590884 hasConcept C29537977 @default.

• next