FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000591146> ?p ?o ?g. }

• W2000591146 endingPage "530" @default.
• W2000591146 startingPage "523" @default.
• W2000591146 abstract "The effects of ethanol and pentobarbital on the function of isolated working hearts from control and ethanol-fed male Long-Evans rats were studied. Hearts from ethanol-fed animals (38% of calories; 10–12 months) exhibited functional tolerance to the cardiodepressive effects of 18–71 mM ethanol in the perfusing medium. Lett ventricular systolic pressure, peak relaxation rate, isovolumic pressure indexes, peak aortic flow rate, cardiac output, and stroke work of the control hearts were depressed to a greater extent than were those indexes of the alcoholic rat hearts during exposure to ethanol in vitro. Differences in the functional responses of controls and alcoholics were not the result of differences in energetics; myocardial O2 consumption, O2 supply-to-utilization ratio, and external work efficiency changed similarly in both groups of hearts during perfusion with ethanol. Cross-tolerance of the alcoholic rat hearts to the in vitro cardiodepressive effects of pentobarbital was also apparent. Peak rate of left ventricular pressure development, peak aortic flow rate, isovolumic pressure indexes, and cardiac output of the control rat hearts were significantly lower than those indexes of the alcoholic rat hearts during perfusion with 0.5 MM pentobarbital. In addition, four of the seven control hearts could not be paced during pentobarbital perfusion using 3V electrical pulses; the pacing voltage had to be raised and right ventricular pacing used to maintain stable function of those hearts at a 321 beats/min pacing rate. Myocardial O2 consumption and O2 supply-to-utilization ratios of control and alcoholic rat hearts were similar, but external work efficiency was slightly higher in the alcoholics than in controls during pentobarbital perfusion. The data indicate that chronic ethanol consumption confers tolerance to ethanol and cross-tolerance to pentobarbital which can be detected in whole heart function in an in vitro setting." @default.
• W2000591146 created "2016-06-24" @default.
• W2000591146 creator A5074673533 @default.
• W2000591146 date "1988-08-01" @default.
• W2000591146 modified "2023-10-18" @default.
• W2000591146 title "Tolerance to Ethanol and Cross-Tolerance to Pentobarbital by Isolated Hearts from Chronic Alcoholic Rats" @default.
• W2000591146 cites W1966461945 @default.
• W2000591146 cites W1967270543 @default.
• W2000591146 cites W1974573459 @default.
• W2000591146 cites W1980284798 @default.
• W2000591146 cites W1980387958 @default.
• W2000591146 cites W1981690194 @default.
• W2000591146 cites W1981943570 @default.
• W2000591146 cites W1982852793 @default.
• W2000591146 cites W1998505097 @default.
• W2000591146 cites W2000331442 @default.
• W2000591146 cites W2048664143 @default.
• W2000591146 cites W2055900715 @default.
• W2000591146 cites W2057843485 @default.
• W2000591146 cites W2059349647 @default.
• W2000591146 cites W2060993192 @default.
• W2000591146 cites W2062510262 @default.
• W2000591146 cites W2063186093 @default.
• W2000591146 cites W2071718689 @default.
• W2000591146 cites W2089028288 @default.
• W2000591146 cites W2107303243 @default.
• W2000591146 cites W2173255728 @default.
• W2000591146 cites W2320701314 @default.
• W2000591146 cites W2337305818 @default.
• W2000591146 cites W2407900559 @default.
• W2000591146 cites W4253900421 @default.
• W2000591146 doi "https://doi.org/10.1111/j.1530-0277.1988.tb00236.x" @default.
• W2000591146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3056074" @default.
• W2000591146 hasPublicationYear "1988" @default.
• W2000591146 type Work @default.
• W2000591146 sameAs 2000591146 @default.
• W2000591146 citedByCount "7" @default.
• W2000591146 crossrefType "journal-article" @default.
• W2000591146 hasAuthorship W2000591146A5074673533 @default.
• W2000591146 hasConcept C126322002 @default.
• W2000591146 hasConcept C139940330 @default.
• W2000591146 hasConcept C146957229 @default.
• W2000591146 hasConcept C164705383 @default.
• W2000591146 hasConcept C185592680 @default.
• W2000591146 hasConcept C26635844 @default.
• W2000591146 hasConcept C2776755955 @default.
• W2000591146 hasConcept C2777953023 @default.
• W2000591146 hasConcept C2780161600 @default.
• W2000591146 hasConcept C39124391 @default.
• W2000591146 hasConcept C42219234 @default.
• W2000591146 hasConcept C55493867 @default.
• W2000591146 hasConcept C71924100 @default.
• W2000591146 hasConcept C84393581 @default.
• W2000591146 hasConceptScore W2000591146C126322002 @default.
• W2000591146 hasConceptScore W2000591146C139940330 @default.
• W2000591146 hasConceptScore W2000591146C146957229 @default.
• W2000591146 hasConceptScore W2000591146C164705383 @default.
• W2000591146 hasConceptScore W2000591146C185592680 @default.
• W2000591146 hasConceptScore W2000591146C26635844 @default.
• W2000591146 hasConceptScore W2000591146C2776755955 @default.
• W2000591146 hasConceptScore W2000591146C2777953023 @default.
• W2000591146 hasConceptScore W2000591146C2780161600 @default.
• W2000591146 hasConceptScore W2000591146C39124391 @default.
• W2000591146 hasConceptScore W2000591146C42219234 @default.
• W2000591146 hasConceptScore W2000591146C55493867 @default.
• W2000591146 hasConceptScore W2000591146C71924100 @default.
• W2000591146 hasConceptScore W2000591146C84393581 @default.
• W2000591146 hasIssue "4" @default.
• W2000591146 hasLocation W20005911461 @default.
• W2000591146 hasLocation W20005911462 @default.
• W2000591146 hasOpenAccess W2000591146 @default.
• W2000591146 hasPrimaryLocation W20005911461 @default.
• W2000591146 hasRelatedWork W1966106627 @default.
• W2000591146 hasRelatedWork W1976018466 @default.
• W2000591146 hasRelatedWork W2046602862 @default.
• W2000591146 hasRelatedWork W2053809643 @default.
• W2000591146 hasRelatedWork W2085629627 @default.
• W2000591146 hasRelatedWork W2328395624 @default.
• W2000591146 hasRelatedWork W2363135161 @default.
• W2000591146 hasRelatedWork W2467857680 @default.
• W2000591146 hasRelatedWork W2899084033 @default.
• W2000591146 hasRelatedWork W963082253 @default.
• W2000591146 hasVolume "12" @default.
• W2000591146 isParatext "false" @default.
• W2000591146 isRetracted "false" @default.
• W2000591146 magId "2000591146" @default.
• W2000591146 workType "article" @default.