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• W2000591211 abstract "Abstract Gingipains are cysteine proteases produced by Porphyromonas gingivalis , one of the major pathogens of periodontitis. They are classified into lysine-specific gingipain (Kgp) and arginine-specific gingipains (Rgps) by the specificity of the proteolytic cutting sites. Gingipains are known to play a major role in the progression of periodontitis by inducing inflammation and tissue destruction in the periodontium, including alveolar bone loss by osteoclasts ; however, the roles of gingipains in osteoclastic bone resorption have not been elucidated yet. Recently, we reported that Kgp but not Rgps and active vitamin D 3 or microbial components such as lipopolysaccharide (LPS) synergistically induced osteoclast formation and activation in a setting where both osteoblasts and osteoclast precursor cells co-exist. While LPS has been regarded as one of the major factors for osteoclastogenesis and alveolar bone loss in periodontitis, our findings revealed that not only LPS but also Kgp plays a pivotal role in alveolar bone loss in periodontitis." @default.
• W2000591211 created "2016-06-24" @default.
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• W2000591211 date "2011-01-01" @default.
• W2000591211 modified "2023-09-26" @default.
• W2000591211 title "Roles of Gingipains in Periodontal Bone Loss" @default.
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• W2000591211 doi "https://doi.org/10.1016/s1349-0079(11)80002-2" @default.
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